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TGF-β1 stimulates migration of type II endometrial cancer cells by down-regulating PTEN via activation of SMAD and ERK1/2 signaling pathways

PTEN acts as a tumor suppressor primarily by antagonizing the PI3K/AKT signaling pathway. PTEN is frequently mutated in human cancers; however, in type II endometrial cancers its mutation rate is very low. Overexpression of TGF-β1 and its receptors has been reported to correlate with metastasis of h...

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Detalles Bibliográficos
Autores principales:	Xiong, Siyuan, Cheng, Jung-Chien, Klausen, Christian, Zhao, Jianfang, Leung, Peter C.K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308649/ https://www.ncbi.nlm.nih.gov/pubmed/27542208 http://dx.doi.org/10.18632/oncotarget.11311

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