YM155 sensitizes TRAIL-induced apoptosis through cathepsin S-dependent down-regulation of Mcl-1 and NF-κB-mediated down-regulation of c-FLIP expression in human renal carcinoma Caki cells

YM155, a small-molecule survivin inhibitor, has been reported for its anti-cancer activity in various cancer cells. In this study, we investigated the effect of YM155 to enhance TRAIL-mediated apoptosis in human renal carcinoma cells. We found that YM155 alone had no effect on apoptosis, however, co...

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Detalles Bibliográficos
Autores principales: Woo, Seon Min, Min, Kyoung-jin, Seo, Bo Ram, Kwon, Taeg Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308669/
https://www.ncbi.nlm.nih.gov/pubmed/27528031
http://dx.doi.org/10.18632/oncotarget.11137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308669/
https://www.ncbi.nlm.nih.gov/pubmed/27528031
http://dx.doi.org/10.18632/oncotarget.11137

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