Cargando…

Promising pharmacological profile of a Kunitz-type inhibitor in murine renal cell carcinoma model

Renal cell carcinoma (RCC), also called kidney cancer or renal adenocarcinoma, is highly resistant to current treatments. It has been previously reported that a Kunitz-type inhibitor domain-containing protein, isolated from the salivary glands of the Amblyomma cajennense tick, triggers apoptosis in...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Souza, Jean Gabriel, Morais, Katia L.P., Anglés-Cano, Eduardo, Boufleur, Pamela, de Mello, Evandro Sobroza, Maria, Durvanei Augusto, Origassa, Clarice Silvia Taemi, Zampolli, Hamilton de Campos, Câmara, Niels Olsen Saraiva, Berra, Carolina Maria, Bosch, Rosemary Viola, Chudzinski-Tavassi, Ana Marisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308724/ https://www.ncbi.nlm.nih.gov/pubmed/27566592 http://dx.doi.org/10.18632/oncotarget.11555

Ejemplares similares

Dynein Function and Protein Clearance Changes in Tumor Cells Induced by a Kunitz-Type Molecule, Amblyomin-X
por: Pacheco, Mario T. F., et al.
Publicado: (2014)

Preclinical evaluation of Amblyomin-X, a Kunitz-type protease inhibitor with antitumor activity
por: Maria, Durvanei A., et al.
Publicado: (2018)

Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells
por: Schmidt, Mariana Costa Braga, et al.
Publicado: (2018)

A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production
por: Maria, Durvanei Augusto, et al.
Publicado: (2012)

Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell
por: Morais, Katia L. P., et al.
Publicado: (2016)

A Lipocalin-Derived Peptide Modulating Fibroblasts and Extracellular Matrix Proteins
por: Carrijo-Carvalho, Linda Christian, et al.
Publicado: (2012)

A Kunitz-type inhibitor from tick salivary glands: A promising novel antitumor drug candidate
por: Lobba, Aline R. M., et al.
Publicado: (2022)

Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity
por: Morais, K. L. P., et al.
Publicado: (2023)

Regression of Albuminuria and Hypertension and Arrest of Severe Renal Injury by a Losartan-Hydrochlorothiazide Association in a Model of Very Advanced Nephropathy
por: Arias, Simone Costa Alarcon, et al.
Publicado: (2013)

New therapeutic target for pediatric anaplastic ependymoma control: study of anti-tumor activity by a Kunitz-type molecule, Amblyomin-X
por: Pavon, Lorena Favaro, et al.
Publicado: (2019)

The importance of molecular characterization in lung cancer
por: de Castro, Gilberto, et al.
Publicado: (2019)

Angiogenic properties of dental pulp stem cells conditioned medium on endothelial cells in vitro and in rodent orthotopic dental pulp regeneration
por: de Cara, Sueli Patricia Harumi Miyagi, et al.
Publicado: (2019)

Immunohistochemical Studies of Stellate Cells in Experimental Cholestasis in Newborn and Adult Rats
por: Gibelli, Nelson Elias Mendes, et al.
Publicado: (2008)

Plant Kunitz Inhibitors and Their Interaction with Proteases: Current and Potential Pharmacological Targets
por: Bonturi, Camila Ramalho, et al.
Publicado: (2022)

MODIFICATION OF THE NORTHROP-KUNITZ MICROCATAPHORESIS CELL
por: Abramson, Harold A.
Publicado: (1929)

Inflammation Induced by Platelet-Activating Viperid Snake Venoms: Perspectives on Thromboinflammation
por: Teixeira, Catarina, et al.
Publicado: (2019)

Prognostic factors for the evolution and reversibility of chronic rejection in pediatric liver transplantation
por: Tannuri, Ana Cristina Aoun, et al.
Publicado: (2016)

Transthyretin Protects against A-Beta Peptide Toxicity by Proteolytic Cleavage of the Peptide: A Mechanism Sensitive to the Kunitz Protease Inhibitor
por: Costa, Rita, et al.
Publicado: (2008)

Exploring the in vivo wound healing effects of a recombinant hemolin from the caterpillar Lonomia obliqua
por: Sato, Ana Claudia, et al.
Publicado: (2016)

Structural insights and molecular dynamics into the inhibitory mechanism of a Kunitz-type trypsin inhibitor from Tamarindus indica L
por: de Medeiros, Amanda Fernandes, et al.
Publicado: (2021)

Hydrogen peroxide (H(2)O(2)) induces leukemic but not normal hematopoietic cell death in a dose-dependent manner
por: Nogueira-Pedro, Amanda, et al.
Publicado: (2013)

Biochemical characterisation of a Kunitz-type inhibitor from Tamarindus indica L. seeds and its efficacy in reducing plasma leptin in an experimental model of obesity
por: de Medeiros, Amanda Fernandes, et al.
Publicado: (2018)

Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma
por: DeOcesano-Pereira, Carlos, et al.
Publicado: (2020)

Arabidopsis Kunitz Trypsin Inhibitors in Defense Against Spider Mites
por: Arnaiz, Ana, et al.
Publicado: (2018)

Tryptogalinin Is a Tick Kunitz Serine Protease Inhibitor with a Unique Intrinsic Disorder
por: Valdés, James J., et al.
Publicado: (2013)

Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model
por: Lichtenstein, Flavio, et al.
Publicado: (2020)

A Regulatory miRNA–mRNA Network Is Associated with Tissue Repair Induced by Mesenchymal Stromal Cells in Acute Kidney Injury
por: de Almeida, Danilo Candido, et al.
Publicado: (2017)

Characterization and Pharmacological Properties of a Novel Multifunctional Kunitz Inhibitor from Erythrina velutina Seeds
por: Machado, Richele J. A., et al.
Publicado: (2013)

Incidental Node Metastasis as an Independent Factor of Worse Disease-Free Survival in Patients with Papillary Thyroid Carcinoma
por: Pinheiro, Renan Aguera, et al.
Publicado: (2023)

Mesenchymal stem cell-like properties of CD133(+) glioblastoma initiating cells
por: Pavon, Lorena Favaro, et al.
Publicado: (2016)

Clinical spectrum and therapeutic approach to hepatocellular injury in patients with hyperthyroidism
por: de Campos Mazo, Daniel Ferraz, et al.
Publicado: (2013)

Decoy Plasminogen Receptor Containing a Selective Kunitz-Inhibitory Domain
por: Kumar, Yogesh, et al.
Publicado: (2014)

Expression profiles of gastric cancer molecular subtypes in remnant tumors
por: Ramos, Marcus Fernando Kodama Pertille, et al.
Publicado: (2021)

Human Chondrocyte Activation by Toxins From Premolis semirufa, an Amazon Rainforest Moth Caterpillar: Identifying an Osteoarthritis Signature
por: Villas-Boas, Isadora M., et al.
Publicado: (2020)

Losac and Lopap Recombinant Proteins from Lonomia obliqua Bristles Positively Modulate the Myoblast Proliferation Process
por: Alvarez, Angela María, et al.
Publicado: (2022)

S. mansoni SmKI-1 Kunitz-domain: Leucine point mutation at P1 site generates enhanced neutrophil elastase inhibitory activity
por: Mambelli, Fábio, et al.
Publicado: (2021)

Discovery of a Distinct Superfamily of Kunitz-Type Toxin (KTT) from Tarantulas
por: Yuan, Chun-Hua, et al.
Publicado: (2008)

Marker assisted accelerated introgression of null allele of kunitz trypsin inhibitor in soybean
por: Kumar, Vineet, et al.
Publicado: (2015)

New Kunitz-Type HCRG Polypeptides from the Sea Anemone Heteractis crispa
por: Gladkikh, Irina, et al.
Publicado: (2015)

Balance between the two kinin receptors in the progression of experimental focal and segmental glomerulosclerosis in mice
por: Pereira, Rafael Luiz, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_is7e0jutrfke3vin2f22u1lh5n