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Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo

The chemokine CXCL12/stromal cell-derived factor-1 is important for leukocyte migration to lymphoid organs and inflamed tissues and stimulates tumor development. In vitro, CXCL12 activity through CXCR4 is abolished by proteolytic processing. However, limited information is available on in vivo effec...

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Detalles Bibliográficos
Autores principales:	Janssens, Rik, Mortier, Anneleen, Boff, Daiane, Vanheule, Vincent, Gouwy, Mieke, Franck, Charlotte, Larsen, Olav, Rosenkilde, Mette M., Van Damme, Jo, Amaral, Flávio A., Teixeira, Mauro M., Struyf, Sofie, Proost, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308738/ https://www.ncbi.nlm.nih.gov/pubmed/27566567 http://dx.doi.org/10.18632/oncotarget.11516

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