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Prognostic significance of survivin in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy
BACKGROUND & AIMS: This study is designed to investigate the expression of survivin and p53 in human rectal cancer tissues and analyze associations between expression and clinical outcomes in terms of disease recurrence and survival duration. RESULTS: During follow-up (median 119.0, range 6.6 to...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308757/ https://www.ncbi.nlm.nih.gov/pubmed/27391438 http://dx.doi.org/10.18632/oncotarget.10445 |
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author | Il Yu, Jeong Lee, Hyebin Park, Hee Chul Choi, Doo Ho Choi, Yoon-La Do, In-Gu Kim, Hee Cheol Lee, Woo Yong Yun, Seong Hyeon Cho, Yong Beom Huh, Jung Wook Park, Yoon Ah Park, Young Suk Park, Joon Oh Kim, Seung Tae Park, Won |
author_facet | Il Yu, Jeong Lee, Hyebin Park, Hee Chul Choi, Doo Ho Choi, Yoon-La Do, In-Gu Kim, Hee Cheol Lee, Woo Yong Yun, Seong Hyeon Cho, Yong Beom Huh, Jung Wook Park, Yoon Ah Park, Young Suk Park, Joon Oh Kim, Seung Tae Park, Won |
author_sort | Il Yu, Jeong |
collection | PubMed |
description | BACKGROUND & AIMS: This study is designed to investigate the expression of survivin and p53 in human rectal cancer tissues and analyze associations between expression and clinical outcomes in terms of disease recurrence and survival duration. RESULTS: During follow-up (median 119.0, range 6.6 to 161.3 months), tumor recurrence was detected in 50 patients (43.1%), and local recurrence developed as a first failure site in 13 patients (11.2%). Positive immunostaining of nuclear and cytoplasmic survivin was observed in about one quarter of patients, and about half of all patients had positive staining for p53. Both survivin and p53 were significant prognostic factors of disease-free survival in the univariate analyses, but only survivin remained a significant prognostic factor in the multivariate analysis. METHODS: We performed a retrospective study with 116 locally advanced rectal cancer patients who underwent total mesorectal excision (TME) followed by postoperative concurrent chemo-radiation therapy (CCRT). Immunohistochemical staining was conducted using antibodies for survivin or p53, and their expression was analyzed using an individual score that combined the percentage of positive cells and staining intensity. CONCLUSIONS: Overexpression of nuclear and cytoplasmic survivin in locally advanced rectal cancer patients was associated with a higher recurrence rate in rectal cancer patients treated with TME followed by postoperative CCRT. |
format | Online Article Text |
id | pubmed-5308757 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53087572017-03-09 Prognostic significance of survivin in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy Il Yu, Jeong Lee, Hyebin Park, Hee Chul Choi, Doo Ho Choi, Yoon-La Do, In-Gu Kim, Hee Cheol Lee, Woo Yong Yun, Seong Hyeon Cho, Yong Beom Huh, Jung Wook Park, Yoon Ah Park, Young Suk Park, Joon Oh Kim, Seung Tae Park, Won Oncotarget Clinical Research Paper BACKGROUND & AIMS: This study is designed to investigate the expression of survivin and p53 in human rectal cancer tissues and analyze associations between expression and clinical outcomes in terms of disease recurrence and survival duration. RESULTS: During follow-up (median 119.0, range 6.6 to 161.3 months), tumor recurrence was detected in 50 patients (43.1%), and local recurrence developed as a first failure site in 13 patients (11.2%). Positive immunostaining of nuclear and cytoplasmic survivin was observed in about one quarter of patients, and about half of all patients had positive staining for p53. Both survivin and p53 were significant prognostic factors of disease-free survival in the univariate analyses, but only survivin remained a significant prognostic factor in the multivariate analysis. METHODS: We performed a retrospective study with 116 locally advanced rectal cancer patients who underwent total mesorectal excision (TME) followed by postoperative concurrent chemo-radiation therapy (CCRT). Immunohistochemical staining was conducted using antibodies for survivin or p53, and their expression was analyzed using an individual score that combined the percentage of positive cells and staining intensity. CONCLUSIONS: Overexpression of nuclear and cytoplasmic survivin in locally advanced rectal cancer patients was associated with a higher recurrence rate in rectal cancer patients treated with TME followed by postoperative CCRT. Impact Journals LLC 2016-07-06 /pmc/articles/PMC5308757/ /pubmed/27391438 http://dx.doi.org/10.18632/oncotarget.10445 Text en Copyright: © 2016 Il Yu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Clinical Research Paper Il Yu, Jeong Lee, Hyebin Park, Hee Chul Choi, Doo Ho Choi, Yoon-La Do, In-Gu Kim, Hee Cheol Lee, Woo Yong Yun, Seong Hyeon Cho, Yong Beom Huh, Jung Wook Park, Yoon Ah Park, Young Suk Park, Joon Oh Kim, Seung Tae Park, Won Prognostic significance of survivin in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy |
title | Prognostic significance of survivin in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy |
title_full | Prognostic significance of survivin in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy |
title_fullStr | Prognostic significance of survivin in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy |
title_full_unstemmed | Prognostic significance of survivin in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy |
title_short | Prognostic significance of survivin in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy |
title_sort | prognostic significance of survivin in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy |
topic | Clinical Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308757/ https://www.ncbi.nlm.nih.gov/pubmed/27391438 http://dx.doi.org/10.18632/oncotarget.10445 |
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