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Anti-proliferative activities of finasteride in benign prostate epithelial cells require stromal fibroblasts and c-Jun gene

This study aimed to identify the role of mouse fibroblast-mediated c-Jun and IGF-1 signaling in the therapeutic effect of finasteride on benign prostatic epithelial cells. BPH-1 cells, alone or with fibroblasts (c-Jun(+/+) or c-Jun(-/-)), were implanted subcutaneously in male nude mice who were then...

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Detalles Bibliográficos
Autores principales:	Wang, Kai, Jin, Song, Fan, Dongdong, Wang, Mingshuai, Xing, Nianzeng, Niu, Yinong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308847/ https://www.ncbi.nlm.nih.gov/pubmed/28196103 http://dx.doi.org/10.1371/journal.pone.0172233

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