Cargando…

Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase1 (NPP1) Inhibitors

Nucleotide pyrophosphatase/phosphodiesterase type 1 (NPP1) is a membrane glycoprotein involved in the hydrolysis of extracellular nucleotides. Its major substrate is ATP which is converted to AMP and diphosphate. NPP1 was proposed as a new therapeutic target in brain cancer and immuno-oncology. Seve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Sang-Yong, Sarkar, Soumya, Bhattarai, Sanjay, Namasivayam, Vigneshwaran, De Jonghe, Steven, Stephan, Holger, Herdewijn, Piet, El-Tayeb, Ali, Müller, Christa E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309242/ https://www.ncbi.nlm.nih.gov/pubmed/28261095 http://dx.doi.org/10.3389/fphar.2017.00054

Ejemplares similares

Physiologic and pathologic functions of the NPP nucleotide pyrophosphatase/phosphodiesterase family focusing on NPP1 in calcification
por: Terkeltaub, Robert
Publicado: (2006)

Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3)
por: Döhler, Christoph, et al.
Publicado: (2018)

Acidosis Is a key regulator of osteoblast ecto‐nucleotidase pyrophosphatase/phosphodiesterase 1 (NPP1) expression and activity
por: Orriss, Isabel R., et al.
Publicado: (2015)

Computational identification and experimental characterization of substrate binding determinants of nucleotide pyrophosphatase/phosphodiesterase 7
por: Parrill, Abby L, et al.
Publicado: (2011)

N-Glycomic and Microscopic Subcellular Localization Analyses of NPP1, 2 and 6 Strongly Indicate that trans-Golgi Compartments Participate in the Golgi to Plastid Traffic of Nucleotide Pyrophosphatase/Phosphodiesterases in Rice
por: Kaneko, Kentaro, et al.
Publicado: (2016)

Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1
por: Kato, Kazuki, et al.
Publicado: (2018)

Development of Novel Ecto-Nucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Inhibitors for Tumor Immunotherapy
por: Wang, Xiang, et al.
Publicado: (2022)

Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) – a promising target for the immunotherapy of cancer
por: Lopez, Vittoria, et al.
Publicado: (2023)

Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity
por: Borza, Razvan, et al.
Publicado: (2021)

ISOLATION OF RAT LIVER PLASMA MEMBRANES : Use of Nucleotide Pyrophosphatase and Phosphodiesterase I as Marker Enzymes
por: Touster, Oscar, et al.
Publicado: (1970)

Purification of Maize Nucleotide Pyrophosphatase/Phosphodiesterase Casts Doubt on the Existence of Zeatin Cis–Trans Isomerase in Plants
por: Hluska, Tomáš, et al.
Publicado: (2017)

Hip Geometry Variation in Homozygous Ectonucleotide Pyrophosphatase/ Phosphodiesterase 1 (ENPP1) Deficient Patients
por: Theng, Elizabeth H, et al.
Publicado: (2021)

Role of ectonucleotide pyrophosphatase/phosphodiesterase 2 in the midline axis formation of zebrafish
por: Frisca, Frisca, et al.
Publicado: (2016)

Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors
por: Ullah, Saif, et al.
Publicado: (2022)

Bioseparation of Four Proteins from Euphorbia characias Latex: Amine Oxidase, Peroxidase, Nucleotide Pyrophosphatase/Phosphodiesterase, and Purple Acid Phosphatase
por: Medda, Rosaria, et al.
Publicado: (2011)

Changes of activity and isoforms of alkaline sphingomyelinase (nucleotide pyrophosphatase phosphodiesterase 7) in bile from patients undergoing endoscopic retrograde cholangiopancreatography
por: Duan, Rui-Dong, et al.
Publicado: (2014)

The hepatic ectonucleotide pyrophosphatase/phosphodiesterase 1 gene mRNA abundance is reduced by insulin and induced by dexamethasone
por: Ma, Huiwen, et al.
Publicado: (2018)

K121Q polymorphism in the Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 gene is associated with acute kidney rejection
por: Sortica, Denise A., et al.
Publicado: (2019)

Nucleotide Pyrophosphatase/Phosphodiesterase 1 Exerts a Negative Effect on Starch Accumulation and Growth in Rice Seedlings under High Temperature and CO(2) Concentration Conditions
por: Kaneko, Kentaro, et al.
Publicado: (2014)

Kinetic Analysis of Substrate Utilization by Native and TNAP-, NPP1-, or PHOSPHO1-Deficient Matrix Vesicles
por: Ciancaglini, Pietro, et al.
Publicado: (2010)

Evaluation of NPP using three models compared with MODIS-NPP data over China
por: Sun, Jinke, et al.
Publicado: (2021)

Cyclic nucleotide phosphodiesterase 1 and vascular aging
por: Yan, Chen
Publicado: (2015)

Proteoliposomes Harboring Alkaline Phosphatase and Nucleotide Pyrophosphatase as Matrix Vesicle Biomimetics
por: Simão, Ana Maria S., et al.
Publicado: (2010)

Npp1 promotes atherosclerosis in ApoE knockout mice
por: Nitschke, Yvonne, et al.
Publicado: (2011)

Expression of NPP1 is regulated during atheromatous plaque calcification
por: Nitschke, Yvonne, et al.
Publicado: (2011)

Biochemical and Structural Studies of Conserved Maf Proteins Revealed Nucleotide Pyrophosphatases with a Preference for Modified Nucleotides
por: Tchigvintsev, Anatoli, et al.
Publicado: (2013)

Aircraft Impact Effects on an Aged NPP
por: Lo Frano, Rosa
Publicado: (2021)

Rapid assessment of cyclone damage using NPP-VIIRS DNB and ancillary data
por: Sarkar, Soma
Publicado: (2021)

Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases
por: Renders, Marleen, et al.
Publicado: (2019)

Insights into the Cellular Function of YhdE, a Nucleotide Pyrophosphatase from Escherichia coli
por: Jin, Jin, et al.
Publicado: (2015)

Recommended tool compounds and drugs for blocking P2X and P2Y receptors
por: Müller, Christa E., et al.
Publicado: (2021)

Modulation of purinergic signaling by NPP-type ectophosphodiesterases
por: Stefan, Cristiana, et al.
Publicado: (2006)

NPP statement on racism, discrimination, and abuse of power
por: Carlezon, William A.
Publicado: (2020)

Inosine triphosphate pyrophosphatase from Trypanosoma brucei cleanses cytosolic pools from deaminated nucleotides
por: Vidal, Antonio E., et al.
Publicado: (2022)

Maf/ham1-like pyrophosphatases of non-canonical nucleotides are host-specific partners of viral RNA-dependent RNA polymerases
por: Valli, Adrian A., et al.
Publicado: (2022)

Lack of Vacuolar H(+) -Pyrophosphatase and Cytosolic Pyrophosphatases Causes Fatal Developmental Defects in Arabidopsis thaliana
por: Fukuda, Mayu, et al.
Publicado: (2020)

Sulfated Polysaccharides from Macroalgae Are Potent Dual Inhibitors of Human ATP-Hydrolyzing Ectonucleotidases NPP1 and CD39
por: Lopez, Vittoria, et al.
Publicado: (2021)

Crystal Structure of Inorganic Pyrophosphatase From Schistosoma japonicum Reveals the Mechanism of Chemicals and Substrate Inhibition
por: Wu, Qun-Feng, et al.
Publicado: (2021)

Residue Network Involved in the Allosteric Regulation of Cystathionine β-Synthase Domain-Containing Pyrophosphatase by Adenine Nucleotides
por: Anashkin, Viktor A., et al.
Publicado: (2019)

Evaluation of NPP Efficiency Using Phase-Transition Batteries
por: Aminov, R. Z., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_a6qadb7me3smrhv72kj1g2mj1a