LSVT-BIG Improves UPDRS III Scores at 4 Weeks in Parkinson's Disease Patients with Wearing Off: A Prospective, Open-Label Study

The efficacy of LSVT-BIG for advanced Parkinson's disease (PD) patients with wearing off remains to be determined. Therefore, we evaluated whether LSVT-BIG improves motor disability in eight PD patients with wearing off. Unified Parkinson's Disease Rating Scale (UPDRS) scores, daily off ti...

Descripción completa

Detalles Bibliográficos
Autores principales: Ueno, Tatsuya, Sasaki, Megumi, Nishijima, Haruo, Funamizu, Yukihisa, Kon, Tomoya, Haga, Rie, Arai, Akira, Suzuki, Chieko, Nunomura, Jin-ichi, Baba, Masayuki, Tomiyama, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309427/
https://www.ncbi.nlm.nih.gov/pubmed/28255499
http://dx.doi.org/10.1155/2017/8130140
_version_ 1782507702537158656
author Ueno, Tatsuya
Sasaki, Megumi
Nishijima, Haruo
Funamizu, Yukihisa
Kon, Tomoya
Haga, Rie
Arai, Akira
Suzuki, Chieko
Nunomura, Jin-ichi
Baba, Masayuki
Tomiyama, Masahiko
author_facet Ueno, Tatsuya
Sasaki, Megumi
Nishijima, Haruo
Funamizu, Yukihisa
Kon, Tomoya
Haga, Rie
Arai, Akira
Suzuki, Chieko
Nunomura, Jin-ichi
Baba, Masayuki
Tomiyama, Masahiko
author_sort Ueno, Tatsuya
collection PubMed
description The efficacy of LSVT-BIG for advanced Parkinson's disease (PD) patients with wearing off remains to be determined. Therefore, we evaluated whether LSVT-BIG improves motor disability in eight PD patients with wearing off. Unified Parkinson's Disease Rating Scale (UPDRS) scores, daily off time, and mobility assessments were evaluated during the “on” time before and after the LSVT-BIG course. LSVT-BIG significantly improved UPDRS III scores at 4 weeks and UPDRS II scores in the “off” state at 12 weeks, with no changes in the other measures. The findings suggest that LSVT-BIG may be an effective therapy for advanced PD patients with wearing off.
format Online
Article
Text
id pubmed-5309427
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-53094272017-03-02 LSVT-BIG Improves UPDRS III Scores at 4 Weeks in Parkinson's Disease Patients with Wearing Off: A Prospective, Open-Label Study Ueno, Tatsuya Sasaki, Megumi Nishijima, Haruo Funamizu, Yukihisa Kon, Tomoya Haga, Rie Arai, Akira Suzuki, Chieko Nunomura, Jin-ichi Baba, Masayuki Tomiyama, Masahiko Parkinsons Dis Research Article The efficacy of LSVT-BIG for advanced Parkinson's disease (PD) patients with wearing off remains to be determined. Therefore, we evaluated whether LSVT-BIG improves motor disability in eight PD patients with wearing off. Unified Parkinson's Disease Rating Scale (UPDRS) scores, daily off time, and mobility assessments were evaluated during the “on” time before and after the LSVT-BIG course. LSVT-BIG significantly improved UPDRS III scores at 4 weeks and UPDRS II scores in the “off” state at 12 weeks, with no changes in the other measures. The findings suggest that LSVT-BIG may be an effective therapy for advanced PD patients with wearing off. Hindawi Publishing Corporation 2017 2017-02-01 /pmc/articles/PMC5309427/ /pubmed/28255499 http://dx.doi.org/10.1155/2017/8130140 Text en Copyright © 2017 Tatsuya Ueno et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ueno, Tatsuya
Sasaki, Megumi
Nishijima, Haruo
Funamizu, Yukihisa
Kon, Tomoya
Haga, Rie
Arai, Akira
Suzuki, Chieko
Nunomura, Jin-ichi
Baba, Masayuki
Tomiyama, Masahiko
LSVT-BIG Improves UPDRS III Scores at 4 Weeks in Parkinson's Disease Patients with Wearing Off: A Prospective, Open-Label Study
title LSVT-BIG Improves UPDRS III Scores at 4 Weeks in Parkinson's Disease Patients with Wearing Off: A Prospective, Open-Label Study
title_full LSVT-BIG Improves UPDRS III Scores at 4 Weeks in Parkinson's Disease Patients with Wearing Off: A Prospective, Open-Label Study
title_fullStr LSVT-BIG Improves UPDRS III Scores at 4 Weeks in Parkinson's Disease Patients with Wearing Off: A Prospective, Open-Label Study
title_full_unstemmed LSVT-BIG Improves UPDRS III Scores at 4 Weeks in Parkinson's Disease Patients with Wearing Off: A Prospective, Open-Label Study
title_short LSVT-BIG Improves UPDRS III Scores at 4 Weeks in Parkinson's Disease Patients with Wearing Off: A Prospective, Open-Label Study
title_sort lsvt-big improves updrs iii scores at 4 weeks in parkinson's disease patients with wearing off: a prospective, open-label study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309427/
https://www.ncbi.nlm.nih.gov/pubmed/28255499
http://dx.doi.org/10.1155/2017/8130140
work_keys_str_mv AT uenotatsuya lsvtbigimprovesupdrsiiiscoresat4weeksinparkinsonsdiseasepatientswithwearingoffaprospectiveopenlabelstudy
AT sasakimegumi lsvtbigimprovesupdrsiiiscoresat4weeksinparkinsonsdiseasepatientswithwearingoffaprospectiveopenlabelstudy
AT nishijimaharuo lsvtbigimprovesupdrsiiiscoresat4weeksinparkinsonsdiseasepatientswithwearingoffaprospectiveopenlabelstudy
AT funamizuyukihisa lsvtbigimprovesupdrsiiiscoresat4weeksinparkinsonsdiseasepatientswithwearingoffaprospectiveopenlabelstudy
AT kontomoya lsvtbigimprovesupdrsiiiscoresat4weeksinparkinsonsdiseasepatientswithwearingoffaprospectiveopenlabelstudy
AT hagarie lsvtbigimprovesupdrsiiiscoresat4weeksinparkinsonsdiseasepatientswithwearingoffaprospectiveopenlabelstudy
AT araiakira lsvtbigimprovesupdrsiiiscoresat4weeksinparkinsonsdiseasepatientswithwearingoffaprospectiveopenlabelstudy
AT suzukichieko lsvtbigimprovesupdrsiiiscoresat4weeksinparkinsonsdiseasepatientswithwearingoffaprospectiveopenlabelstudy
AT nunomurajinichi lsvtbigimprovesupdrsiiiscoresat4weeksinparkinsonsdiseasepatientswithwearingoffaprospectiveopenlabelstudy
AT babamasayuki lsvtbigimprovesupdrsiiiscoresat4weeksinparkinsonsdiseasepatientswithwearingoffaprospectiveopenlabelstudy
AT tomiyamamasahiko lsvtbigimprovesupdrsiiiscoresat4weeksinparkinsonsdiseasepatientswithwearingoffaprospectiveopenlabelstudy

Ejemplares similares