Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome

In addition to mutations in genes, aberrant enhancer element activity at non-coding regions of the genome is a key driver of tumorigenesis. Here, we perform epigenomic enhancer profiling of a cohort of more than forty genetically diverse human colorectal cancer (CRC) specimens. Using normal colonic...

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Detalles Bibliográficos
Autores principales: Cohen, Andrea J., Saiakhova, Alina, Corradin, Olivia, Luppino, Jennifer M., Lovrenert, Katreya, Bartels, Cynthia F., Morrow, James J., Mack, Stephen C., Dhillon, Gursimran, Beard, Lydia, Myeroff, Lois, Kalady, Matthew F., Willis, Joseph, Bradner, James E., Keri, Ruth A., Berger, Nathan A., Pruett-Miller, Shondra M., Markowitz, Sanford D., Scacheri, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309719/
https://www.ncbi.nlm.nih.gov/pubmed/28169291
http://dx.doi.org/10.1038/ncomms14400

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