A substrate-bound structure of cyanobacterial biliverdin reductase identifies stacked substrates as critical for activity

Biliverdin reductase catalyses the last step in haem degradation and produces the major lipophilic antioxidant bilirubin via reduction of biliverdin, using NAD(P)H as a cofactor. Despite the importance of biliverdin reductase in maintaining the redox balance, the molecular details of the reaction it...

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Detalles Bibliográficos
Autores principales: Takao, Haruna, Hirabayashi, Kei, Nishigaya, Yuki, Kouriki, Haruna, Nakaniwa, Tetsuko, Hagiwara, Yoshinori, Harada, Jiro, Sato, Hideaki, Yamazaki, Toshimasa, Sakakibara, Yoichi, Suiko, Masahito, Asada, Yujiro, Takahashi, Yasuhiro, Yamamoto, Ken, Fukuyama, Keiichi, Sugishima, Masakazu, Wada, Kei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309722/
https://www.ncbi.nlm.nih.gov/pubmed/28169272
http://dx.doi.org/10.1038/ncomms14397

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