A screening strategy for the discovery of drugs that reduce C/EBPβ-LIP translation with potential calorie restriction mimetic properties

An important part of the beneficial effects of calorie restriction (CR) on healthspan and lifespan is mediated through regulation of protein synthesis that is under control of the mechanistic target of rapamycin complex 1 (mTORC1). As one of its activities, mTORC1 stimulates translation into the met...

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Detalles Bibliográficos
Autores principales: Zaini, Mohamad A., Müller, Christine, Ackermann, Tobias, Reinshagen, Jeanette, Kortman, Gertrud, Pless, Ole, Calkhoven, Cornelis F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309760/
https://www.ncbi.nlm.nih.gov/pubmed/28198412
http://dx.doi.org/10.1038/srep42603

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