Human IDO-competent, long-lived immunoregulatory dendritic cells induced by intracellular pathogen, and their fate in humanized mice

Targeting of myeloid-dendritic cell receptor DC-SIGN by numerous chronic infectious agents, including Porphyromonas gingivalis, is shown to drive-differentiation of monocytes into dysfunctional mDCs. These mDCs exhibit alterations of their fine-tuned homeostatic function and contribute to dysregulat...

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Detalles Bibliográficos
Autores principales: Tyagi, Rajeev K., Miles, Brodie, Parmar, Rajesh, Garg, Neeraj K., Dalai, Sarat K., Baban, Babak, Cutler, Christopher W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309771/
https://www.ncbi.nlm.nih.gov/pubmed/28198424
http://dx.doi.org/10.1038/srep41083

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