Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I–IV)...

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Autores principales: Schütte, Moritz, Risch, Thomas, Abdavi-Azar, Nilofar, Boehnke, Karsten, Schumacher, Dirk, Keil, Marlen, Yildiriman, Reha, Jandrasits, Christine, Borodina, Tatiana, Amstislavskiy, Vyacheslav, Worth, Catherine L., Schweiger, Caroline, Liebs, Sandra, Lange, Martin, Warnatz, Hans- Jörg, Butcher, Lee M., Barrett, James E., Sultan, Marc, Wierling, Christoph, Golob-Schwarzl, Nicole, Lax, Sigurd, Uranitsch, Stefan, Becker, Michael, Welte, Yvonne, Regan, Joseph Lewis, Silvestrov, Maxine, Kehler, Inge, Fusi, Alberto, Kessler, Thomas, Herwig, Ralf, Landegren, Ulf, Wienke, Dirk, Nilsson, Mats, Velasco, Juan A., Garin-Chesa, Pilar, Reinhard, Christoph, Beck, Stephan, Schäfer, Reinhold, Regenbrecht, Christian R. A., Henderson, David, Lange, Bodo, Haybaeck, Johannes, Keilholz, Ulrich, Hoffmann, Jens, Lehrach, Hans, Yaspo, Marie-Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309787/
https://www.ncbi.nlm.nih.gov/pubmed/28186126
http://dx.doi.org/10.1038/ncomms14262

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