Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mou...

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Autores principales: Smith, Nikaïa, Pietrancosta, Nicolas, Davidson, Sophia, Dutrieux, Jacques, Chauveau, Lise, Cutolo, Pasquale, Dy, Michel, Scott-Algara, Daniel, Manoury, Bénédicte, Zirafi, Onofrio, McCort-Tranchepain, Isabelle, Durroux, Thierry, Bachelerie, Françoise, Schwartz, Olivier, Münch, Jan, Wack, Andreas, Nisole, Sébastien, Herbeuval, Jean-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309800/
https://www.ncbi.nlm.nih.gov/pubmed/28181493
http://dx.doi.org/10.1038/ncomms14253
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author Smith, Nikaïa
Pietrancosta, Nicolas
Davidson, Sophia
Dutrieux, Jacques
Chauveau, Lise
Cutolo, Pasquale
Dy, Michel
Scott-Algara, Daniel
Manoury, Bénédicte
Zirafi, Onofrio
McCort-Tranchepain, Isabelle
Durroux, Thierry
Bachelerie, Françoise
Schwartz, Olivier
Münch, Jan
Wack, Andreas
Nisole, Sébastien
Herbeuval, Jean-Philippe
author_facet Smith, Nikaïa
Pietrancosta, Nicolas
Davidson, Sophia
Dutrieux, Jacques
Chauveau, Lise
Cutolo, Pasquale
Dy, Michel
Scott-Algara, Daniel
Manoury, Bénédicte
Zirafi, Onofrio
McCort-Tranchepain, Isabelle
Durroux, Thierry
Bachelerie, Françoise
Schwartz, Olivier
Münch, Jan
Wack, Andreas
Nisole, Sébastien
Herbeuval, Jean-Philippe
author_sort Smith, Nikaïa
collection PubMed
description Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential ‘on-off' switch of pDC activity with therapeutic potential.
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spelling pubmed-53098002017-02-27 Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement Smith, Nikaïa Pietrancosta, Nicolas Davidson, Sophia Dutrieux, Jacques Chauveau, Lise Cutolo, Pasquale Dy, Michel Scott-Algara, Daniel Manoury, Bénédicte Zirafi, Onofrio McCort-Tranchepain, Isabelle Durroux, Thierry Bachelerie, Françoise Schwartz, Olivier Münch, Jan Wack, Andreas Nisole, Sébastien Herbeuval, Jean-Philippe Nat Commun Article Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential ‘on-off' switch of pDC activity with therapeutic potential. Nature Publishing Group 2017-02-09 /pmc/articles/PMC5309800/ /pubmed/28181493 http://dx.doi.org/10.1038/ncomms14253 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Smith, Nikaïa
Pietrancosta, Nicolas
Davidson, Sophia
Dutrieux, Jacques
Chauveau, Lise
Cutolo, Pasquale
Dy, Michel
Scott-Algara, Daniel
Manoury, Bénédicte
Zirafi, Onofrio
McCort-Tranchepain, Isabelle
Durroux, Thierry
Bachelerie, Françoise
Schwartz, Olivier
Münch, Jan
Wack, Andreas
Nisole, Sébastien
Herbeuval, Jean-Philippe
Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement
title Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement
title_full Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement
title_fullStr Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement
title_full_unstemmed Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement
title_short Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement
title_sort natural amines inhibit activation of human plasmacytoid dendritic cells through cxcr4 engagement
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309800/
https://www.ncbi.nlm.nih.gov/pubmed/28181493
http://dx.doi.org/10.1038/ncomms14253
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