SMAD transcription factors are altered in cell models of HD and regulate HTT expression

Transcriptional dysregulation is observable in multiple animal and cell models of Huntington's disease, as well as in human blood and post-mortem caudate. This contributes to HD pathogenesis, although the exact mechanism by which this occurs is unknown. We therefore utilised a dynamic model in...

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Detalles Bibliográficos
Autores principales: Bowles, KR, Stone, T, Holmans, P, Allen, ND, Dunnett, SB, Jones, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310119/
https://www.ncbi.nlm.nih.gov/pubmed/27988204
http://dx.doi.org/10.1016/j.cellsig.2016.12.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310119/
https://www.ncbi.nlm.nih.gov/pubmed/27988204
http://dx.doi.org/10.1016/j.cellsig.2016.12.005

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