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Histatin peptides: Pharmacological functions and their applications in dentistry
There are many human oral antimicrobial peptides responsible for playing important roles including maintenance, repairing of oral tissues (hard or soft) and defense against oral microbes. In this review we have highlighted the biochemistry, physiology and proteomics of human oral histatin peptides,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310145/ https://www.ncbi.nlm.nih.gov/pubmed/28223859 http://dx.doi.org/10.1016/j.jsps.2016.04.027 |
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author | Khurshid, Zohaib Najeeb, Shariq Mali, Maria Moin, Syed Faraz Raza, Syed Qasim Zohaib, Sana Sefat, Farshid Zafar, Muhammad Sohail |
author_facet | Khurshid, Zohaib Najeeb, Shariq Mali, Maria Moin, Syed Faraz Raza, Syed Qasim Zohaib, Sana Sefat, Farshid Zafar, Muhammad Sohail |
author_sort | Khurshid, Zohaib |
collection | PubMed |
description | There are many human oral antimicrobial peptides responsible for playing important roles including maintenance, repairing of oral tissues (hard or soft) and defense against oral microbes. In this review we have highlighted the biochemistry, physiology and proteomics of human oral histatin peptides, secreted from parotid and submandibular salivary glands in human. The significance of these peptides includes capability for ionic binding that can kill fungal Candida albicans. They have histidine rich amino acid sequences (7–12 family members; corresponding to residues 12–24, 13–24, 12–25, 13–25, 5–11, and 5–12, respectively) for Histatin-3. However, Histatin-3 can be synthesized proteolytically from histatin 5 or 6. Due to their fungicidal response and high biocompatibility (little or no toxicity), these peptides can be considered as therapeutic agents with most probable applications for example, artificial saliva for denture wearers and salivary gland dysfunction conditions. The objectives of current article are to explore the human histatin peptides for its types, chemical and biological aspects. In addition, the potential for therapeutic bio-dental applications has been elaborated. |
format | Online Article Text |
id | pubmed-5310145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-53101452017-02-21 Histatin peptides: Pharmacological functions and their applications in dentistry Khurshid, Zohaib Najeeb, Shariq Mali, Maria Moin, Syed Faraz Raza, Syed Qasim Zohaib, Sana Sefat, Farshid Zafar, Muhammad Sohail Saudi Pharm J Review There are many human oral antimicrobial peptides responsible for playing important roles including maintenance, repairing of oral tissues (hard or soft) and defense against oral microbes. In this review we have highlighted the biochemistry, physiology and proteomics of human oral histatin peptides, secreted from parotid and submandibular salivary glands in human. The significance of these peptides includes capability for ionic binding that can kill fungal Candida albicans. They have histidine rich amino acid sequences (7–12 family members; corresponding to residues 12–24, 13–24, 12–25, 13–25, 5–11, and 5–12, respectively) for Histatin-3. However, Histatin-3 can be synthesized proteolytically from histatin 5 or 6. Due to their fungicidal response and high biocompatibility (little or no toxicity), these peptides can be considered as therapeutic agents with most probable applications for example, artificial saliva for denture wearers and salivary gland dysfunction conditions. The objectives of current article are to explore the human histatin peptides for its types, chemical and biological aspects. In addition, the potential for therapeutic bio-dental applications has been elaborated. Elsevier 2017-01 2016-05-04 /pmc/articles/PMC5310145/ /pubmed/28223859 http://dx.doi.org/10.1016/j.jsps.2016.04.027 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Khurshid, Zohaib Najeeb, Shariq Mali, Maria Moin, Syed Faraz Raza, Syed Qasim Zohaib, Sana Sefat, Farshid Zafar, Muhammad Sohail Histatin peptides: Pharmacological functions and their applications in dentistry |
title | Histatin peptides: Pharmacological functions and their applications in dentistry |
title_full | Histatin peptides: Pharmacological functions and their applications in dentistry |
title_fullStr | Histatin peptides: Pharmacological functions and their applications in dentistry |
title_full_unstemmed | Histatin peptides: Pharmacological functions and their applications in dentistry |
title_short | Histatin peptides: Pharmacological functions and their applications in dentistry |
title_sort | histatin peptides: pharmacological functions and their applications in dentistry |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310145/ https://www.ncbi.nlm.nih.gov/pubmed/28223859 http://dx.doi.org/10.1016/j.jsps.2016.04.027 |
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