Design, synthesis, molecular modeling and biological evaluation of novel diaryl heterocyclic analogs as potential selective cyclooxygenase-2 (COX-2) inhibitors

New series of 3,4-diaryl-2-thioxoimidazolidin-4-ones and 3-alkylthio-4,5-diaryl-4H-1,2,4-triazoles were designed, synthesized and evaluated for their activity as anti-inflammatory agents. Compounds 20, 21, 23 and 34 are highly selective inhibitors of COX-2 enzyme at a concentration of 100 mM relativ...

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Detalles Bibliográficos
Autores principales: Al-Turki, Deema A., Al-Omar, Mohamed A., Abou-zeid, Laila A., Shehata, Ihsan A., Al-Awady, Mohammed S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310148/
https://www.ncbi.nlm.nih.gov/pubmed/28223863
http://dx.doi.org/10.1016/j.jsps.2015.07.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310148/
https://www.ncbi.nlm.nih.gov/pubmed/28223863
http://dx.doi.org/10.1016/j.jsps.2015.07.001

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