What can mathematical modelling say about CHO metabolism and protein glycosylation?

Chinese hamster ovary cells have been in the spotlight for process optimization in recent years, due to being the major, long established cell factory for the production of recombinant proteins. A deep, quantitative understanding of CHO metabolism and mechanisms involved in protein glycosylation has...

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Detalles Bibliográficos
Autores principales: Galleguillos, Sarah N., Ruckerbauer, David, Gerstl, Matthias P., Borth, Nicole, Hanscho, Michael, Zanghellini, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2017
Materias:
Short Survey
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310201/
https://www.ncbi.nlm.nih.gov/pubmed/28228925
http://dx.doi.org/10.1016/j.csbj.2017.01.005
Descripción
Sumario:Chinese hamster ovary cells have been in the spotlight for process optimization in recent years, due to being the major, long established cell factory for the production of recombinant proteins. A deep, quantitative understanding of CHO metabolism and mechanisms involved in protein glycosylation has proven to be attainable through the development of high throughput technologies. Here we review the most notable accomplishments in the field of modelling CHO metabolism and protein glycosylation.

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