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Exploring estrogenic activity in lung cancer

It is well known that a connection between xenobiotics inhalation, especially tobacco combustion and Lung Cancer development is strongly significant and indisputable. However, recent studies provide evidence indicating that another factors such as, estrogens are also involved in lung carcinoma biolo...

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Autores principales: Słowikowski, Bartosz Kazimierz, Lianeri, Margarita, Jagodziński, Paweł Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310573/
https://www.ncbi.nlm.nih.gov/pubmed/27783191
http://dx.doi.org/10.1007/s11033-016-4086-8
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author Słowikowski, Bartosz Kazimierz
Lianeri, Margarita
Jagodziński, Paweł Piotr
author_facet Słowikowski, Bartosz Kazimierz
Lianeri, Margarita
Jagodziński, Paweł Piotr
author_sort Słowikowski, Bartosz Kazimierz
collection PubMed
description It is well known that a connection between xenobiotics inhalation, especially tobacco combustion and Lung Cancer development is strongly significant and indisputable. However, recent studies provide evidence indicating that another factors such as, estrogens are also involved in lung carcinoma biology and metabolism. Although the status of estrogen receptors (ER), in both cancerous and healthy lung tissue has been well documented, there is still inconclusive data with respect of which isoform of the receptor is present in the lungs. However according to several studies, ERβ appears to be predominant form. Apart from ERs, estrogens can work through a recently discovered G-coupled estrogen receptor. Binding with both types of the receptors causes a signal, which leads to i.e. enhanced cell proliferation. There are many published reports which suggest that estrogen can be synthesized in situ in lung cancer. Some disturbances in the activity and expression levels of enzymes involved in estrogen synthesis were proved. This suggests that increased amounts of sex-steroid hormones can affect cells biology and be the reason of the accelerated development and pathogenesis of lung cancer. There also exist phenomena which associate estrogenic metabolism and tobacco combustion and its carcinogenic influence on the lungs. Compounds present in cigarette smoke induce the activity of CYP1B1, the enzyme responsible for estrogenic metabolism and synthesis of their cateholic derivatives. These structures during their redox cycle are able to release reactive oxygen species or form DNA adduct, which generally leads to destruction of genetic material. This process may explain the synergistic effect of smoking and estrogens on estrogen-dependent lung cancer development.
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spelling pubmed-53105732017-02-28 Exploring estrogenic activity in lung cancer Słowikowski, Bartosz Kazimierz Lianeri, Margarita Jagodziński, Paweł Piotr Mol Biol Rep Review It is well known that a connection between xenobiotics inhalation, especially tobacco combustion and Lung Cancer development is strongly significant and indisputable. However, recent studies provide evidence indicating that another factors such as, estrogens are also involved in lung carcinoma biology and metabolism. Although the status of estrogen receptors (ER), in both cancerous and healthy lung tissue has been well documented, there is still inconclusive data with respect of which isoform of the receptor is present in the lungs. However according to several studies, ERβ appears to be predominant form. Apart from ERs, estrogens can work through a recently discovered G-coupled estrogen receptor. Binding with both types of the receptors causes a signal, which leads to i.e. enhanced cell proliferation. There are many published reports which suggest that estrogen can be synthesized in situ in lung cancer. Some disturbances in the activity and expression levels of enzymes involved in estrogen synthesis were proved. This suggests that increased amounts of sex-steroid hormones can affect cells biology and be the reason of the accelerated development and pathogenesis of lung cancer. There also exist phenomena which associate estrogenic metabolism and tobacco combustion and its carcinogenic influence on the lungs. Compounds present in cigarette smoke induce the activity of CYP1B1, the enzyme responsible for estrogenic metabolism and synthesis of their cateholic derivatives. These structures during their redox cycle are able to release reactive oxygen species or form DNA adduct, which generally leads to destruction of genetic material. This process may explain the synergistic effect of smoking and estrogens on estrogen-dependent lung cancer development. Springer Netherlands 2016-10-25 2017 /pmc/articles/PMC5310573/ /pubmed/27783191 http://dx.doi.org/10.1007/s11033-016-4086-8 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Słowikowski, Bartosz Kazimierz
Lianeri, Margarita
Jagodziński, Paweł Piotr
Exploring estrogenic activity in lung cancer
title Exploring estrogenic activity in lung cancer
title_full Exploring estrogenic activity in lung cancer
title_fullStr Exploring estrogenic activity in lung cancer
title_full_unstemmed Exploring estrogenic activity in lung cancer
title_short Exploring estrogenic activity in lung cancer
title_sort exploring estrogenic activity in lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310573/
https://www.ncbi.nlm.nih.gov/pubmed/27783191
http://dx.doi.org/10.1007/s11033-016-4086-8
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