Cargando…

Transcriptional regulation of PNPLA3 and its impact on susceptibility to nonalcoholic fatty liver Disease (NAFLD) in humans

The increased expression of PNPLA3(148M) leads to hepatosteatosis in mice. This study aims to investigate the genetic control of hepatic PNPLA3 transcription and to explore its impact on NAFLD risk in humans. Through a locus-wide expression quantitative trait loci (eQTL) mapping in two human liver s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Wanqing, Anstee, Quentin M, Wang, Xiaoliang, Gawrieh, Samer, Gamazon, Eric R., Athinarayanan, Shaminie, Liu, Yang-Lin, Darlay, Rebecca, Cordell, Heather J, Daly, Ann K, Day, Chris P, Chalasani, Naga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310654/ https://www.ncbi.nlm.nih.gov/pubmed/27744419 http://dx.doi.org/10.18632/aging.101067

Ejemplares similares

Genetic Polymorphism of Cytochrome P450 4F2, Vitamin E Level and Histological Response in Adults and Children with Nonalcoholic Fatty Liver Disease Who Participated in PIVENS and TONIC Clinical Trials
por: Athinarayanan, Shaminie, et al.
Publicado: (2014)

Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPARα‐FGF21 Axis
por: Athinarayanan, Shaminie, et al.
Publicado: (2020)

Non-Alcoholic Fatty Liver Disease: Current Perspectives and Future Direction in Disease pathogenesis, Treatment and Diagnosis
por: Athinarayanan, Shaminie, et al.
Publicado: (2012)

Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease (NAFLD) susceptibility and severity: A meta-analysis
por: Dai, Guangrong, et al.
Publicado: (2019)

Phosphatidylethanolamines Are Associated with Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Adults and Induce Liver Cell Metabolic Perturbations and Hepatic Stellate Cell Activation
por: Shama, Samaa, et al.
Publicado: (2023)

Integrative omics analysis identifies macrophage migration inhibitory factor signaling pathways underlying human hepatic fibrogenesis and fibrosis
por: Liu, Zhipeng, et al.
Publicado: (2019)

Additive Effects of the Risk Alleles of PNPLA3 and TM6SF2 on Non-alcoholic Fatty Liver Disease (NAFLD) in a Chinese Population
por: Wang, Xiaoliang, et al.
Publicado: (2016)

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
por: Romeo, Stefano, et al.
Publicado: (2008)

Effect of Gut Microbiota and PNPLA3 rs738409 Variant on Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Youth
por: Monga Kravetz, Ayesha, et al.
Publicado: (2020)

A PDCD1 Role in the Genetic Predisposition to NAFLD-HCC?
por: Eldafashi, Nardeen, et al.
Publicado: (2021)

Post hoc analyses of surrogate markers of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis in patients with type 2 diabetes in a digitally supported continuous care intervention: an open-label, non-randomised controlled study
por: Vilar-Gomez, Eduardo, et al.
Publicado: (2019)

Nonalcoholic fatty liver disease: new treatments
por: Hardy, Timothy, et al.
Publicado: (2015)

NAFLD in Polycystic Ovary Syndrome: Association with PNPLA3 and Metabolic Features
por: Recuero, Amanda Medeiros, et al.
Publicado: (2022)

NAFLD-Associated HCC: Progress and Opportunities
por: Geh, Daniel, et al.
Publicado: (2021)

Risk factors for hepatocellular carcinoma in cirrhosis due to nonalcoholic fatty liver disease: A multicenter, case-control study
por: Corey, Kathleen E, et al.
Publicado: (2017)

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice
por: Lindén, Daniel, et al.
Publicado: (2019)

Changing Trends of Cirrhotic and Noncirrhotic Hepatocellular Carcinoma in the Era of Directly-Acting Antiviral Agents
por: Mathur, Karan, et al.
Publicado: (2021)

Glycogenosis is common in nonalcoholic fatty liver disease and is independently associated with ballooning, but lower steatosis and lower fibrosis
por: Allende, Daniela S, et al.
Publicado: (2021)

Correlations between PNPLA3 Gene Polymorphisms and NAFLD in Type 2 Diabetic Patients
por: Gavril, Oana Irina, et al.
Publicado: (2021)

Communicating PNPLA3 genetic risk status for NAFLD among Mexican-origin men
por: Villavicencio, Edgar A., et al.
Publicado: (2023)

Interaction of SAMM50-rs738491, PARVB-rs5764455 and PNPLA3-rs738409 Increases Susceptibility to Nonalcoholic Steatohepatitis
por: Xu, Ke, et al.
Publicado: (2022)

Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals
por: Masuoka, Howard C, et al.
Publicado: (2013)

Genetic Predisposition in NAFLD and NASH: Impact on Severity of Liver Disease and Response to Treatment
por: Dongiovanni, Paola, et al.
Publicado: (2013)

Dynamic Alterations to Hepatic MicroRNA-29a in Response to Long-Term High-Fat Diet and EtOH Feeding
por: Liang, Tiebing, et al.
Publicado: (2023)

Quantitative digital pathology reveals association of cell-specific PNPLA3 transcription with NAFLD disease activity
por: Sandhu, Bynvant, et al.
Publicado: (2019)

Interaction between Lifestyle Changes and PNPLA3 Genotype in NAFLD Patients during the COVID-19 Lockdown
por: Cinque, Felice, et al.
Publicado: (2022)

Interaction between the PNPLA3 Gene and Nutritional Factors on NAFLD Development: The Korean Genome and Epidemiology Study
por: Oh, Sooyeon, et al.
Publicado: (2022)

PNPLA3 rs738409 underlies treatment response in nonalcoholic fatty liver disease
por: Wang, Jin-Zhi, et al.
Publicado: (2018)

Distinctive Features and Outcomes of Hepatocellular Carcinoma in Patients With Alcohol-Related Liver Disease: A US Multicenter Study
por: deLemos, Andrew, et al.
Publicado: (2020)

Prognostic accuracy of FIB‐4, NAFLD fibrosis score and APRI for NAFLD‐related events: A systematic review
por: Lee, Jenny, et al.
Publicado: (2021)

PNPLA3 genotype and fibrosis-4 index predict cardiovascular diseases of Japanese patients with histopathologically-confirmed NAFLD
por: Akuta, Norio, et al.
Publicado: (2021)

Automated assessment of steatosis in murine fatty liver
por: Sethunath, Deepak, et al.
Publicado: (2018)

Racial Disparities in Liver Transplantation for Hepatocellular Carcinoma Are Not Explained by Differences in Comorbidities, Liver Disease Severity, or Tumor Burden
por: Dakhoul, Lara, et al.
Publicado: (2018)

Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease
por: Hotta, Kikuko, et al.
Publicado: (2010)

PNPLA3 and TM6SF2 polymorphisms in Brazilian patients with nonalcoholic fatty liver disease
por: Lisboa, Quelson Coelho, et al.
Publicado: (2020)

The OMICs Window into Nonalcoholic Fatty Liver Disease (NAFLD)
por: Carulli, Lucia, et al.
Publicado: (2019)

SAT-LB125 Broad Spectrum Effects of a Ketogenic Diet Delivered by Remote Continuous Care on Inflammation and Immune Modulators in Type 2 Diabetes and Prediabetes
por: Phinney, Stephen, et al.
Publicado: (2020)

Current Status in Testing for Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH)
por: Drescher, Hannah K., et al.
Publicado: (2019)

NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects
por: Sliz, Eeva, et al.
Publicado: (2018)

Identification of deleterious rare variants in MTTP, PNPLA3, and TM6SF2 in Japanese males and association studies with NAFLD
por: Boonvisut, Supichaya, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_0q2g29gvpjq8pt7gucaic20594