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Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae

A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast) due to an inability to sense or repair DNA d...

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Detalles Bibliográficos
Autores principales:	Tombline, Gregory, Millen, Jonathan I., Polevoda, Bogdan, Rapaport, Matan, Baxter, Bonnie, Van Meter, Michael, Gilbertson, Matthew, Madrey, Joe, Piazza, Gary A., Rasmussen, Lynn, Wennerberg, Krister, White, E. Lucile, Nitiss, John L., Goldfarb, David S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310657/ https://www.ncbi.nlm.nih.gov/pubmed/28077781 http://dx.doi.org/10.18632/aging.101114

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