Aging enhances liver fibrotic response in mice through hampering extracellular matrix remodeling

Clinical data identify age as a factor for severe liver fibrosis. We evaluate whether and how aging modulates the fibrotic response in a mouse model. Liver fibrosis was induced by CCl(4) injections (thrice weekly for 2 weeks) in 7 weeks- and 15 months-old mice (young and old, respectively). Livers w...

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Detalles Bibliográficos
Autores principales: Delire, Bénédicte, Lebrun, Valérie, Selvais, Charlotte, Henriet, Patrick, Bertrand, Amélie, Horsmans, Yves, Leclercq, Isabelle A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310658/
https://www.ncbi.nlm.nih.gov/pubmed/27941216
http://dx.doi.org/10.18632/aging.101124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310658/
https://www.ncbi.nlm.nih.gov/pubmed/27941216
http://dx.doi.org/10.18632/aging.101124

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