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High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells
AKR1C1 is a member of the AKR1C family, which not only plays an important role in hormone metabolism but is believed to be involved in carcinogen metabolism. Our previous study demonstrated that AKR1C1 was highly expressed in lung tumor tissues as compared with the tumor-adjacent tissues. Small-cell...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310699/ https://www.ncbi.nlm.nih.gov/pubmed/28210161 http://dx.doi.org/10.2147/LCTT.S90694 |
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author | Tian, He Li, Xing Jiang, Wenli Lv, Cuiting Sun, Weizhang Huang, Caiguo Chen, Ruohua |
author_facet | Tian, He Li, Xing Jiang, Wenli Lv, Cuiting Sun, Weizhang Huang, Caiguo Chen, Ruohua |
author_sort | Tian, He |
collection | PubMed |
description | AKR1C1 is a member of the AKR1C family, which not only plays an important role in hormone metabolism but is believed to be involved in carcinogen metabolism. Our previous study demonstrated that AKR1C1 was highly expressed in lung tumor tissues as compared with the tumor-adjacent tissues. Small-cell lung cancer (SCLC) is a special type of lung cancer. Surgical treatment of SCLC is usually difficult due to the high degree of malignancy and early metastasis, and difficulty in obtaining clinical specimens. There is not much basic or clinical research on SCLC in the People’s Republic of China even in recent years. To investigate the mechanism of AKR1C1 in the pathogenesis of SCLC, the present study used H446 cell line to see whether AKR1C1 could affect the proliferation or migration of SCLC cells, and used a lentivirus to build the AKR1C1 overexpression and under-expression cell lines. The results indicated that AKR1C1 was an important inducement in the proliferation and migration of H446 cells. AKR1C1 promoted cell proliferation and played a vital role in the migration of SCLC cells. These results were also verified in nude mice in vivo. In conclusion, AKR1C1 plays an important role in the development and progression of SCLC and may represent an independent biomarker for assessment of the primary prognosis and therapy of SCLC. |
format | Online Article Text |
id | pubmed-5310699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-53106992017-02-16 High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells Tian, He Li, Xing Jiang, Wenli Lv, Cuiting Sun, Weizhang Huang, Caiguo Chen, Ruohua Lung Cancer (Auckl) Original Research AKR1C1 is a member of the AKR1C family, which not only plays an important role in hormone metabolism but is believed to be involved in carcinogen metabolism. Our previous study demonstrated that AKR1C1 was highly expressed in lung tumor tissues as compared with the tumor-adjacent tissues. Small-cell lung cancer (SCLC) is a special type of lung cancer. Surgical treatment of SCLC is usually difficult due to the high degree of malignancy and early metastasis, and difficulty in obtaining clinical specimens. There is not much basic or clinical research on SCLC in the People’s Republic of China even in recent years. To investigate the mechanism of AKR1C1 in the pathogenesis of SCLC, the present study used H446 cell line to see whether AKR1C1 could affect the proliferation or migration of SCLC cells, and used a lentivirus to build the AKR1C1 overexpression and under-expression cell lines. The results indicated that AKR1C1 was an important inducement in the proliferation and migration of H446 cells. AKR1C1 promoted cell proliferation and played a vital role in the migration of SCLC cells. These results were also verified in nude mice in vivo. In conclusion, AKR1C1 plays an important role in the development and progression of SCLC and may represent an independent biomarker for assessment of the primary prognosis and therapy of SCLC. Dove Medical Press 2016-05-02 /pmc/articles/PMC5310699/ /pubmed/28210161 http://dx.doi.org/10.2147/LCTT.S90694 Text en © 2016 Tian et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited |
spellingShingle | Original Research Tian, He Li, Xing Jiang, Wenli Lv, Cuiting Sun, Weizhang Huang, Caiguo Chen, Ruohua High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells |
title | High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells |
title_full | High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells |
title_fullStr | High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells |
title_full_unstemmed | High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells |
title_short | High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells |
title_sort | high expression of akr1c1 is associated with proliferation and migration of small-cell lung cancer cells |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310699/ https://www.ncbi.nlm.nih.gov/pubmed/28210161 http://dx.doi.org/10.2147/LCTT.S90694 |
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