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The genome of Onchocerca volvulus, agent of river blindness

Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of the disease relies largely on mass administration of a single drug, and the development of new drugs and vaccines depends on...

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Autores principales: Cotton, James A., Bennuru, Sasisekhar, Grote, Alexandra, Harsha, Bhavana, Tracey, Alan, Beech, Robin, Doyle, Stephen R., Dunn, Matthew, Dunning Hotopp, Julie C., Holroyd, Nancy, Kikuchi, Taisei, Lambert, Olivia, Mhashilkar, Amruta, Mutowo, Prudence, Nursimulu, Nirvana, Ribeiro, Jose M. C., Rogers, Matthew B., Stanley, Eleanor, Swapna, Lakshmipuram S., Tsai, Isheng J., Unnasch, Thomas R., Voronin, Denis, Parkinson, John, Nutman, Thomas B., Ghedin, Elodie, Berriman, Matthew, Lustigman, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310847/
https://www.ncbi.nlm.nih.gov/pubmed/27869790
http://dx.doi.org/10.1038/nmicrobiol.2016.216
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author Cotton, James A.
Bennuru, Sasisekhar
Grote, Alexandra
Harsha, Bhavana
Tracey, Alan
Beech, Robin
Doyle, Stephen R.
Dunn, Matthew
Dunning Hotopp, Julie C.
Holroyd, Nancy
Kikuchi, Taisei
Lambert, Olivia
Mhashilkar, Amruta
Mutowo, Prudence
Nursimulu, Nirvana
Ribeiro, Jose M. C.
Rogers, Matthew B.
Stanley, Eleanor
Swapna, Lakshmipuram S.
Tsai, Isheng J.
Unnasch, Thomas R.
Voronin, Denis
Parkinson, John
Nutman, Thomas B.
Ghedin, Elodie
Berriman, Matthew
Lustigman, Sara
author_facet Cotton, James A.
Bennuru, Sasisekhar
Grote, Alexandra
Harsha, Bhavana
Tracey, Alan
Beech, Robin
Doyle, Stephen R.
Dunn, Matthew
Dunning Hotopp, Julie C.
Holroyd, Nancy
Kikuchi, Taisei
Lambert, Olivia
Mhashilkar, Amruta
Mutowo, Prudence
Nursimulu, Nirvana
Ribeiro, Jose M. C.
Rogers, Matthew B.
Stanley, Eleanor
Swapna, Lakshmipuram S.
Tsai, Isheng J.
Unnasch, Thomas R.
Voronin, Denis
Parkinson, John
Nutman, Thomas B.
Ghedin, Elodie
Berriman, Matthew
Lustigman, Sara
author_sort Cotton, James A.
collection PubMed
description Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of the disease relies largely on mass administration of a single drug, and the development of new drugs and vaccines depends on a better knowledge of parasite biology. Here, we describe the chromosomes of O. volvulus and its Wolbachia endosymbiont. We provide the highest-quality sequence assembly for any parasitic nematode to date, giving a glimpse into the evolution of filarial parasite chromosomes and proteomes. This resource was used to investigate gene families with key functions that could be potentially exploited as targets for future drugs. Using metabolic reconstruction of the nematode and its endosymbiont, we identified enzymes that are likely to be essential for O. volvulus viability. In addition, we have generated a list of proteins that could be targeted by Federal-Drug-Agency-approved but repurposed drugs, providing starting points for anti-onchocerciasis drug development.
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spelling pubmed-53108472017-02-15 The genome of Onchocerca volvulus, agent of river blindness Cotton, James A. Bennuru, Sasisekhar Grote, Alexandra Harsha, Bhavana Tracey, Alan Beech, Robin Doyle, Stephen R. Dunn, Matthew Dunning Hotopp, Julie C. Holroyd, Nancy Kikuchi, Taisei Lambert, Olivia Mhashilkar, Amruta Mutowo, Prudence Nursimulu, Nirvana Ribeiro, Jose M. C. Rogers, Matthew B. Stanley, Eleanor Swapna, Lakshmipuram S. Tsai, Isheng J. Unnasch, Thomas R. Voronin, Denis Parkinson, John Nutman, Thomas B. Ghedin, Elodie Berriman, Matthew Lustigman, Sara Nat Microbiol Article Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of the disease relies largely on mass administration of a single drug, and the development of new drugs and vaccines depends on a better knowledge of parasite biology. Here, we describe the chromosomes of O. volvulus and its Wolbachia endosymbiont. We provide the highest-quality sequence assembly for any parasitic nematode to date, giving a glimpse into the evolution of filarial parasite chromosomes and proteomes. This resource was used to investigate gene families with key functions that could be potentially exploited as targets for future drugs. Using metabolic reconstruction of the nematode and its endosymbiont, we identified enzymes that are likely to be essential for O. volvulus viability. In addition, we have generated a list of proteins that could be targeted by Federal-Drug-Agency-approved but repurposed drugs, providing starting points for anti-onchocerciasis drug development. 2016-11-21 /pmc/articles/PMC5310847/ /pubmed/27869790 http://dx.doi.org/10.1038/nmicrobiol.2016.216 Text en Reprints and permissions information is available at www.nature.com/reprints. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Cotton, James A.
Bennuru, Sasisekhar
Grote, Alexandra
Harsha, Bhavana
Tracey, Alan
Beech, Robin
Doyle, Stephen R.
Dunn, Matthew
Dunning Hotopp, Julie C.
Holroyd, Nancy
Kikuchi, Taisei
Lambert, Olivia
Mhashilkar, Amruta
Mutowo, Prudence
Nursimulu, Nirvana
Ribeiro, Jose M. C.
Rogers, Matthew B.
Stanley, Eleanor
Swapna, Lakshmipuram S.
Tsai, Isheng J.
Unnasch, Thomas R.
Voronin, Denis
Parkinson, John
Nutman, Thomas B.
Ghedin, Elodie
Berriman, Matthew
Lustigman, Sara
The genome of Onchocerca volvulus, agent of river blindness
title The genome of Onchocerca volvulus, agent of river blindness
title_full The genome of Onchocerca volvulus, agent of river blindness
title_fullStr The genome of Onchocerca volvulus, agent of river blindness
title_full_unstemmed The genome of Onchocerca volvulus, agent of river blindness
title_short The genome of Onchocerca volvulus, agent of river blindness
title_sort genome of onchocerca volvulus, agent of river blindness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310847/
https://www.ncbi.nlm.nih.gov/pubmed/27869790
http://dx.doi.org/10.1038/nmicrobiol.2016.216
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