Potential Value of miR-221/222 as Diagnostic, Prognostic, and Therapeutic Biomarkers for Diseases

microRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by base pairing with their target messenger RNAs. Dysregulation of miRNAs is involved in the pathological initiation and progression of many human diseases. miR-221 and miR-222 (miR-221/222) are two highly homologous miRNAs,...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Jialin, Ouyang, Yuanming, Che, Junyi, Li, Xiaoming, Zhao, Yi, Yang, Kejia, Zhao, Xiaotian, Chen, Yinghui, Fan, Cunyi, Yuan, Weien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311065/
https://www.ncbi.nlm.nih.gov/pubmed/28261196
http://dx.doi.org/10.3389/fimmu.2017.00056
_version_ 1782507960478466048
author Song, Jialin
Ouyang, Yuanming
Che, Junyi
Li, Xiaoming
Zhao, Yi
Yang, Kejia
Zhao, Xiaotian
Chen, Yinghui
Fan, Cunyi
Yuan, Weien
author_facet Song, Jialin
Ouyang, Yuanming
Che, Junyi
Li, Xiaoming
Zhao, Yi
Yang, Kejia
Zhao, Xiaotian
Chen, Yinghui
Fan, Cunyi
Yuan, Weien
author_sort Song, Jialin
collection PubMed
description microRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by base pairing with their target messenger RNAs. Dysregulation of miRNAs is involved in the pathological initiation and progression of many human diseases. miR-221 and miR-222 (miR-221/222) are two highly homologous miRNAs, and they are significantly overexpressed in several types of human diseases. Silencing miR-221/222 could represent a promising approach for therapeutic studies. In the present review, we will describe the potential value of miR-221/222 as diagnostic, prognostic, and therapeutic biomarkers in various diseases including cancer and inflammatory diseases.
format Online
Article
Text
id pubmed-5311065
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-53110652017-03-03 Potential Value of miR-221/222 as Diagnostic, Prognostic, and Therapeutic Biomarkers for Diseases Song, Jialin Ouyang, Yuanming Che, Junyi Li, Xiaoming Zhao, Yi Yang, Kejia Zhao, Xiaotian Chen, Yinghui Fan, Cunyi Yuan, Weien Front Immunol Immunology microRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by base pairing with their target messenger RNAs. Dysregulation of miRNAs is involved in the pathological initiation and progression of many human diseases. miR-221 and miR-222 (miR-221/222) are two highly homologous miRNAs, and they are significantly overexpressed in several types of human diseases. Silencing miR-221/222 could represent a promising approach for therapeutic studies. In the present review, we will describe the potential value of miR-221/222 as diagnostic, prognostic, and therapeutic biomarkers in various diseases including cancer and inflammatory diseases. Frontiers Media S.A. 2017-02-16 /pmc/articles/PMC5311065/ /pubmed/28261196 http://dx.doi.org/10.3389/fimmu.2017.00056 Text en Copyright © 2017 Song, Ouyang, Che, Li, Zhao, Yang, Zhao, Chen, Fan and Yuan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Song, Jialin
Ouyang, Yuanming
Che, Junyi
Li, Xiaoming
Zhao, Yi
Yang, Kejia
Zhao, Xiaotian
Chen, Yinghui
Fan, Cunyi
Yuan, Weien
Potential Value of miR-221/222 as Diagnostic, Prognostic, and Therapeutic Biomarkers for Diseases
title Potential Value of miR-221/222 as Diagnostic, Prognostic, and Therapeutic Biomarkers for Diseases
title_full Potential Value of miR-221/222 as Diagnostic, Prognostic, and Therapeutic Biomarkers for Diseases
title_fullStr Potential Value of miR-221/222 as Diagnostic, Prognostic, and Therapeutic Biomarkers for Diseases
title_full_unstemmed Potential Value of miR-221/222 as Diagnostic, Prognostic, and Therapeutic Biomarkers for Diseases
title_short Potential Value of miR-221/222 as Diagnostic, Prognostic, and Therapeutic Biomarkers for Diseases
title_sort potential value of mir-221/222 as diagnostic, prognostic, and therapeutic biomarkers for diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311065/
https://www.ncbi.nlm.nih.gov/pubmed/28261196
http://dx.doi.org/10.3389/fimmu.2017.00056
work_keys_str_mv AT songjialin potentialvalueofmir221222asdiagnosticprognosticandtherapeuticbiomarkersfordiseases
AT ouyangyuanming potentialvalueofmir221222asdiagnosticprognosticandtherapeuticbiomarkersfordiseases
AT chejunyi potentialvalueofmir221222asdiagnosticprognosticandtherapeuticbiomarkersfordiseases
AT lixiaoming potentialvalueofmir221222asdiagnosticprognosticandtherapeuticbiomarkersfordiseases
AT zhaoyi potentialvalueofmir221222asdiagnosticprognosticandtherapeuticbiomarkersfordiseases
AT yangkejia potentialvalueofmir221222asdiagnosticprognosticandtherapeuticbiomarkersfordiseases
AT zhaoxiaotian potentialvalueofmir221222asdiagnosticprognosticandtherapeuticbiomarkersfordiseases
AT chenyinghui potentialvalueofmir221222asdiagnosticprognosticandtherapeuticbiomarkersfordiseases
AT fancunyi potentialvalueofmir221222asdiagnosticprognosticandtherapeuticbiomarkersfordiseases
AT yuanweien potentialvalueofmir221222asdiagnosticprognosticandtherapeuticbiomarkersfordiseases

Ejemplares similares