Systemic Regulators of Skeletal Muscle Regeneration in Obesity

Skeletal muscle maintenance is a dynamic process and undergoes constant repair and regeneration. However, skeletal muscle regenerative capacity declines in obesity. In this review, we focus on obesity-associated changes in inflammation, metabolism, and impaired insulin signaling, which are pathologi...

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Autores principales: Sinha, Indranil, Sakthivel, Dharaniya, Varon, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311070/
https://www.ncbi.nlm.nih.gov/pubmed/28261159
http://dx.doi.org/10.3389/fendo.2017.00029
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author Sinha, Indranil
Sakthivel, Dharaniya
Varon, David E.
author_facet Sinha, Indranil
Sakthivel, Dharaniya
Varon, David E.
author_sort Sinha, Indranil
collection PubMed
description Skeletal muscle maintenance is a dynamic process and undergoes constant repair and regeneration. However, skeletal muscle regenerative capacity declines in obesity. In this review, we focus on obesity-associated changes in inflammation, metabolism, and impaired insulin signaling, which are pathologically dysregulated and ultimately result in a loss of muscle mass and function. In addition, we examine the relationships between skeletal muscle, liver, and visceral adipose tissue in an obese state.
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spelling pubmed-53110702017-03-03 Systemic Regulators of Skeletal Muscle Regeneration in Obesity Sinha, Indranil Sakthivel, Dharaniya Varon, David E. Front Endocrinol (Lausanne) Endocrinology Skeletal muscle maintenance is a dynamic process and undergoes constant repair and regeneration. However, skeletal muscle regenerative capacity declines in obesity. In this review, we focus on obesity-associated changes in inflammation, metabolism, and impaired insulin signaling, which are pathologically dysregulated and ultimately result in a loss of muscle mass and function. In addition, we examine the relationships between skeletal muscle, liver, and visceral adipose tissue in an obese state. Frontiers Media S.A. 2017-02-16 /pmc/articles/PMC5311070/ /pubmed/28261159 http://dx.doi.org/10.3389/fendo.2017.00029 Text en Copyright © 2017 Sinha, Sakthivel and Varon. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Sinha, Indranil
Sakthivel, Dharaniya
Varon, David E.
Systemic Regulators of Skeletal Muscle Regeneration in Obesity
title Systemic Regulators of Skeletal Muscle Regeneration in Obesity
title_full Systemic Regulators of Skeletal Muscle Regeneration in Obesity
title_fullStr Systemic Regulators of Skeletal Muscle Regeneration in Obesity
title_full_unstemmed Systemic Regulators of Skeletal Muscle Regeneration in Obesity
title_short Systemic Regulators of Skeletal Muscle Regeneration in Obesity
title_sort systemic regulators of skeletal muscle regeneration in obesity
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311070/
https://www.ncbi.nlm.nih.gov/pubmed/28261159
http://dx.doi.org/10.3389/fendo.2017.00029
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