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Disease impact on the quality of life of children with inflammatory bowel disease

AIM: To assess the impact of disease characteristics on the quality of life (QOL) in children with inflammatory bowel diseases (IBD). METHODS: This was a cross-sectional study conducted at the First Department of Pediatrics of the University of Athens at the “Aghia Sophia” Children’s Hospital. Child...

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Autores principales: Chouliaras, Giorgos, Margoni, Daphne, Dimakou, Konstantina, Fessatou, Smaragdi, Panayiotou, Ioanna, Roma-Giannikou, Eleftheria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311096/
https://www.ncbi.nlm.nih.gov/pubmed/28246481
http://dx.doi.org/10.3748/wjg.v23.i6.1067
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author Chouliaras, Giorgos
Margoni, Daphne
Dimakou, Konstantina
Fessatou, Smaragdi
Panayiotou, Ioanna
Roma-Giannikou, Eleftheria
author_facet Chouliaras, Giorgos
Margoni, Daphne
Dimakou, Konstantina
Fessatou, Smaragdi
Panayiotou, Ioanna
Roma-Giannikou, Eleftheria
author_sort Chouliaras, Giorgos
collection PubMed
description AIM: To assess the impact of disease characteristics on the quality of life (QOL) in children with inflammatory bowel diseases (IBD). METHODS: This was a cross-sectional study conducted at the First Department of Pediatrics of the University of Athens at the “Aghia Sophia” Children’s Hospital. Children diagnosed with Crohn’s disease (CD) or ulcerative colitis (UC), who were followed as outpatients or during a hospitalization, participated, after informed consent was obtained from their legal representative. QOL was assessed by the IMPACT-III questionnaire. Demographic data and disease characteristics were also collected. Statistical analyses included parametric (Student’s t-test and Pearson’s r) and non-parametric (Mann-Whitney test, Fisher’s test and Spearman’s rho) procedures. RESULTS: Ninety-nine patients (UC: 37, 73.0% females, CD: 62, 51.6% females), aged 12.8 ± 2.6 years were included. Overall, as well as, sub-domain scores did not differ between UC and CD (overall score: 73.9 ± 13.3 vs 77.5 ± 11.2, respectively, P = 0.16). In the entire sample, total score was related to physician’s global assessment (PGA, patients classified as “mild/moderate” active disease had, on average, 14.8 ± 2.7 points lower total scores compared to those “in remission”, P < 0.001) and age at IMPACT completion (Pearson’s r = 0.29, P = 0.05). Disease activity assessed by the indices Pediatric Ulcerative Colitis activity index, Pediatric Crohn’s disease activity index or PGA was significantly associated with all subdomains scores. Presence of extraintestinal manifestations had a negative impact on emotional and social functioning domains. CONCLUSION: Disease activity is the main correlate of QOL in children with IBD, underlining the importance of achieving and sustaining clinical remission
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spelling pubmed-53110962017-02-28 Disease impact on the quality of life of children with inflammatory bowel disease Chouliaras, Giorgos Margoni, Daphne Dimakou, Konstantina Fessatou, Smaragdi Panayiotou, Ioanna Roma-Giannikou, Eleftheria World J Gastroenterol Observational Study AIM: To assess the impact of disease characteristics on the quality of life (QOL) in children with inflammatory bowel diseases (IBD). METHODS: This was a cross-sectional study conducted at the First Department of Pediatrics of the University of Athens at the “Aghia Sophia” Children’s Hospital. Children diagnosed with Crohn’s disease (CD) or ulcerative colitis (UC), who were followed as outpatients or during a hospitalization, participated, after informed consent was obtained from their legal representative. QOL was assessed by the IMPACT-III questionnaire. Demographic data and disease characteristics were also collected. Statistical analyses included parametric (Student’s t-test and Pearson’s r) and non-parametric (Mann-Whitney test, Fisher’s test and Spearman’s rho) procedures. RESULTS: Ninety-nine patients (UC: 37, 73.0% females, CD: 62, 51.6% females), aged 12.8 ± 2.6 years were included. Overall, as well as, sub-domain scores did not differ between UC and CD (overall score: 73.9 ± 13.3 vs 77.5 ± 11.2, respectively, P = 0.16). In the entire sample, total score was related to physician’s global assessment (PGA, patients classified as “mild/moderate” active disease had, on average, 14.8 ± 2.7 points lower total scores compared to those “in remission”, P < 0.001) and age at IMPACT completion (Pearson’s r = 0.29, P = 0.05). Disease activity assessed by the indices Pediatric Ulcerative Colitis activity index, Pediatric Crohn’s disease activity index or PGA was significantly associated with all subdomains scores. Presence of extraintestinal manifestations had a negative impact on emotional and social functioning domains. CONCLUSION: Disease activity is the main correlate of QOL in children with IBD, underlining the importance of achieving and sustaining clinical remission Baishideng Publishing Group Inc 2017-02-14 2017-02-14 /pmc/articles/PMC5311096/ /pubmed/28246481 http://dx.doi.org/10.3748/wjg.v23.i6.1067 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Observational Study
Chouliaras, Giorgos
Margoni, Daphne
Dimakou, Konstantina
Fessatou, Smaragdi
Panayiotou, Ioanna
Roma-Giannikou, Eleftheria
Disease impact on the quality of life of children with inflammatory bowel disease
title Disease impact on the quality of life of children with inflammatory bowel disease
title_full Disease impact on the quality of life of children with inflammatory bowel disease
title_fullStr Disease impact on the quality of life of children with inflammatory bowel disease
title_full_unstemmed Disease impact on the quality of life of children with inflammatory bowel disease
title_short Disease impact on the quality of life of children with inflammatory bowel disease
title_sort disease impact on the quality of life of children with inflammatory bowel disease
topic Observational Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311096/
https://www.ncbi.nlm.nih.gov/pubmed/28246481
http://dx.doi.org/10.3748/wjg.v23.i6.1067
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