Cargando…

β-Adrenoceptor activation enhances L-type calcium channel currents in anterior piriform cortex pyramidal cells of neonatal mice: implication for odor learning

Early odor preference learning occurs in one-week-old rodents when a novel odor is paired with a tactile stimulation mimicking maternal care. β-Adrenoceptors and L-type calcium channels (LTCCs) in the anterior piriform cortex (aPC) are critically involved in this learning. However, whether β-adrenoc...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghosh, Abhinaba, Mukherjee, Bandhan, Chen, Xihua, Yuan, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311384/
https://www.ncbi.nlm.nih.gov/pubmed/28202717
http://dx.doi.org/10.1101/lm.044818.116
_version_ 1782508022468182016
author Ghosh, Abhinaba
Mukherjee, Bandhan
Chen, Xihua
Yuan, Qi
author_facet Ghosh, Abhinaba
Mukherjee, Bandhan
Chen, Xihua
Yuan, Qi
author_sort Ghosh, Abhinaba
collection PubMed
description Early odor preference learning occurs in one-week-old rodents when a novel odor is paired with a tactile stimulation mimicking maternal care. β-Adrenoceptors and L-type calcium channels (LTCCs) in the anterior piriform cortex (aPC) are critically involved in this learning. However, whether β-adrenoceptors interact directly with LTCCs in aPC pyramidal cells is unknown. Here we show that pyramidal cells expressed significant LTCC currents that declined with age. β-Adrenoceptor activation via isoproterenol age-dependently enhanced LTCC currents. Nifedipine-sensitive, isoproterenol enhancement of calcium currents was only observed in post-natal day 7–10 mice. APC β-adrenoceptor activation induced early odor preference learning was blocked by nifedipine coinfusion.
format Online
Article
Text
id pubmed-5311384
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Cold Spring Harbor Laboratory Press
record_format MEDLINE/PubMed
spelling pubmed-53113842018-03-01 β-Adrenoceptor activation enhances L-type calcium channel currents in anterior piriform cortex pyramidal cells of neonatal mice: implication for odor learning Ghosh, Abhinaba Mukherjee, Bandhan Chen, Xihua Yuan, Qi Learn Mem Brief Communication Early odor preference learning occurs in one-week-old rodents when a novel odor is paired with a tactile stimulation mimicking maternal care. β-Adrenoceptors and L-type calcium channels (LTCCs) in the anterior piriform cortex (aPC) are critically involved in this learning. However, whether β-adrenoceptors interact directly with LTCCs in aPC pyramidal cells is unknown. Here we show that pyramidal cells expressed significant LTCC currents that declined with age. β-Adrenoceptor activation via isoproterenol age-dependently enhanced LTCC currents. Nifedipine-sensitive, isoproterenol enhancement of calcium currents was only observed in post-natal day 7–10 mice. APC β-adrenoceptor activation induced early odor preference learning was blocked by nifedipine coinfusion. Cold Spring Harbor Laboratory Press 2017-03 /pmc/articles/PMC5311384/ /pubmed/28202717 http://dx.doi.org/10.1101/lm.044818.116 Text en © 2017 Ghosh et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Communication
Ghosh, Abhinaba
Mukherjee, Bandhan
Chen, Xihua
Yuan, Qi
β-Adrenoceptor activation enhances L-type calcium channel currents in anterior piriform cortex pyramidal cells of neonatal mice: implication for odor learning
title β-Adrenoceptor activation enhances L-type calcium channel currents in anterior piriform cortex pyramidal cells of neonatal mice: implication for odor learning
title_full β-Adrenoceptor activation enhances L-type calcium channel currents in anterior piriform cortex pyramidal cells of neonatal mice: implication for odor learning
title_fullStr β-Adrenoceptor activation enhances L-type calcium channel currents in anterior piriform cortex pyramidal cells of neonatal mice: implication for odor learning
title_full_unstemmed β-Adrenoceptor activation enhances L-type calcium channel currents in anterior piriform cortex pyramidal cells of neonatal mice: implication for odor learning
title_short β-Adrenoceptor activation enhances L-type calcium channel currents in anterior piriform cortex pyramidal cells of neonatal mice: implication for odor learning
title_sort β-adrenoceptor activation enhances l-type calcium channel currents in anterior piriform cortex pyramidal cells of neonatal mice: implication for odor learning
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311384/
https://www.ncbi.nlm.nih.gov/pubmed/28202717
http://dx.doi.org/10.1101/lm.044818.116
work_keys_str_mv AT ghoshabhinaba badrenoceptoractivationenhancesltypecalciumchannelcurrentsinanteriorpiriformcortexpyramidalcellsofneonatalmiceimplicationforodorlearning
AT mukherjeebandhan badrenoceptoractivationenhancesltypecalciumchannelcurrentsinanteriorpiriformcortexpyramidalcellsofneonatalmiceimplicationforodorlearning
AT chenxihua badrenoceptoractivationenhancesltypecalciumchannelcurrentsinanteriorpiriformcortexpyramidalcellsofneonatalmiceimplicationforodorlearning
AT yuanqi badrenoceptoractivationenhancesltypecalciumchannelcurrentsinanteriorpiriformcortexpyramidalcellsofneonatalmiceimplicationforodorlearning