Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively

Lin28a inhibits the biogenesis of let-7 miRNAs by triggering the polyuridylation and degradation of their precursors by terminal uridylyltransferases TUT4/7 and 3′-5′ exoribonuclease Dis3l2, respectively. Previously, we showed that Lin28a also controls the production of neuro-specific miRNA-9 via a...

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Detalles Bibliográficos
Autores principales: Nowak, Jakub Stanislaw, Hobor, Fruzsina, Downie Ruiz Velasco, Angela, Choudhury, Nila Roy, Heikel, Gregory, Kerr, Alastair, Ramos, Andres, Michlewski, Gracjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311490/
https://www.ncbi.nlm.nih.gov/pubmed/27881476
http://dx.doi.org/10.1261/rna.059196.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311490/
https://www.ncbi.nlm.nih.gov/pubmed/27881476
http://dx.doi.org/10.1261/rna.059196.116

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