Focal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices

The focal adhesion kinase (FAK) regulates the dynamics of integrin-based cell adhesions important for motility. FAK’s activity regulation is involved in stress-sensing and focal-adhesion turnover. The effect of FAK on 3D migration and cellular mechanics is unclear. We analyzed FAK knock-out mouse em...

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Detalles Bibliográficos
Autores principales: Mierke, Claudia T., Fischer, Tony, Puder, Stefanie, Kunschmann, Tom, Soetje, Birga, Ziegler, Wolfgang H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311912/
https://www.ncbi.nlm.nih.gov/pubmed/28202937
http://dx.doi.org/10.1038/srep42780

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