Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells

Chemogenomic profiling is a powerful and unbiased approach to elucidate pharmacological targets and the mechanism of bioactive compounds. Until recently, genome-wide, high-resolution experiments of this nature have been limited to fungal systems due to lack of mammalian genome-wide deletion collecti...

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Autores principales: Estoppey, David, Hewett, Jeffrey W., Guy, Chantale T., Harrington, Edmund, Thomas, Jason R., Schirle, Markus, Cuttat, Rachel, Waldt, Annick, Gerrits, Bertran, Yang, Zinger, Schuierer, Sven, Pan, Xuewen, Xie, Kevin, Carbone, Walter, Knehr, Judith, Lindeman, Alicia, Russ, Carsten, Frias, Elizabeth, Hoffman, Gregory R., Varadarajan, Malini, Ramadan, Nadire, Reece-Hoyes, John S., Wang, Qiong, Chen, Xin, McAllister, Gregory, Roma, Guglielmo, Bouwmeester, Tewis, Hoepfner, Dominic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311948/
https://www.ncbi.nlm.nih.gov/pubmed/28205648
http://dx.doi.org/10.1038/srep42728

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