Aurora A regulates expression of AR-V7 in models of castrate resistant prostate cancer

Androgen receptor variants (AR-Vs) provide a mechanism of therapy evasion in castrate-resistant prostate cancer (CRPC), yet mechanisms of regulation remain largely unknown. Here we investigate the role of Aurora A kinase on AR-Vs in models of CRPC and show depletion of Aurora A reduces AR-V target g...

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Detalles Bibliográficos
Autores principales: Jones, Dominic, Noble, Martin, Wedge, Steve R., Robson, Craig N., Gaughan, Luke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311967/
https://www.ncbi.nlm.nih.gov/pubmed/28205582
http://dx.doi.org/10.1038/srep40957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311967/
https://www.ncbi.nlm.nih.gov/pubmed/28205582
http://dx.doi.org/10.1038/srep40957

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