A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells

Active tuberculosis (TB) and latent Mycobacterium tuberculosis infection both require lengthy treatments to achieve durable cures. This problem has partly been attributable to the existence of nonreplicating M. tuberculosis “persisters” that are difficult to kill using conventional anti-TB treatment...

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Detalles Bibliográficos
Autores principales: Sukheja, Paridhi, Kumar, Pradeep, Mittal, Nisha, Li, Shao-Gang, Singleton, Eric, Russo, Riccardo, Perryman, Alexander L., Shrestha, Riju, Awasthi, Divya, Husain, Seema, Soteropoulos, Patricia, Brukh, Roman, Connell, Nancy, Freundlich, Joel S., Alland, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312080/
https://www.ncbi.nlm.nih.gov/pubmed/28196957
http://dx.doi.org/10.1128/mBio.02022-16

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