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Enhancing NAD(+) salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease

Familial forms of Parkinson's disease (PD) caused by mutations in PINK1 are linked to mitochondrial impairment. Defective mitochondria are also found in Drosophila models of PD with pink1 mutations. The co-enzyme nicotinamide adenine dinucleotide (NAD(+)) is essential for both generating energy...

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Detalles Bibliográficos
Autores principales:	Lehmann, Susann, Loh, Samantha H. Y., Martins, L. Miguel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312101/ https://www.ncbi.nlm.nih.gov/pubmed/28011627 http://dx.doi.org/10.1242/bio.022186

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