Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes

To predict drug-induced serious adverse events (SAE) in clinical trials, a model using a panel of cells derived from human induced pluripotent stem cells (hiPSCs) of individuals with different susceptibilities could facilitate major advancements in translational research in terms of safety and pharm...

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Detalles Bibliográficos
Autores principales: Shinozawa, Tadahiro, Nakamura, Koki, Shoji, Masanobu, Morita, Maya, Kimura, Maya, Furukawa, Hatsue, Ueda, Hiroki, Shiramoto, Masanari, Matsuguma, Kyoko, Kaji, Yoshikazu, Ikushima, Ippei, Yono, Makoto, Liou, Shyh-Yuh, Nagai, Hirofumi, Nakanishi, Atsushi, Yamamoto, Keiji, Izumo, Seigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312248/
https://www.ncbi.nlm.nih.gov/pubmed/28111276
http://dx.doi.org/10.1016/j.stemcr.2016.12.014

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