CDK5RAP2 Is Required to Maintain the Germ Cell Pool during Embryonic Development

Gene products linked to microcephaly have been studied foremost for their role in brain development, while their function in the development of other organs has been largely neglected. Here, we report the critical role of Cdk5rap2 in maintaining the germ cell pool during embryonic development. We hi...

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Detalles Bibliográficos
Autores principales: Zaqout, Sami, Bessa, Paraskevi, Krämer, Nadine, Stoltenburg-Didinger, Gisela, Kaindl, Angela M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312265/
https://www.ncbi.nlm.nih.gov/pubmed/28162995
http://dx.doi.org/10.1016/j.stemcr.2017.01.002
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author Zaqout, Sami
Bessa, Paraskevi
Krämer, Nadine
Stoltenburg-Didinger, Gisela
Kaindl, Angela M.
author_facet Zaqout, Sami
Bessa, Paraskevi
Krämer, Nadine
Stoltenburg-Didinger, Gisela
Kaindl, Angela M.
author_sort Zaqout, Sami
collection PubMed
description Gene products linked to microcephaly have been studied foremost for their role in brain development, while their function in the development of other organs has been largely neglected. Here, we report the critical role of Cdk5rap2 in maintaining the germ cell pool during embryonic development. We highlight that infertility in Cdk5rap2 mutant mice is secondary to a lack of spermatogenic cells in adult mice as a result of an early developmental defect in the germ cells through mitotic delay, prolonged cell cycle, and apoptosis.
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spelling pubmed-53122652017-02-22 CDK5RAP2 Is Required to Maintain the Germ Cell Pool during Embryonic Development Zaqout, Sami Bessa, Paraskevi Krämer, Nadine Stoltenburg-Didinger, Gisela Kaindl, Angela M. Stem Cell Reports Report Gene products linked to microcephaly have been studied foremost for their role in brain development, while their function in the development of other organs has been largely neglected. Here, we report the critical role of Cdk5rap2 in maintaining the germ cell pool during embryonic development. We highlight that infertility in Cdk5rap2 mutant mice is secondary to a lack of spermatogenic cells in adult mice as a result of an early developmental defect in the germ cells through mitotic delay, prolonged cell cycle, and apoptosis. Elsevier 2017-02-02 /pmc/articles/PMC5312265/ /pubmed/28162995 http://dx.doi.org/10.1016/j.stemcr.2017.01.002 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Report
Zaqout, Sami
Bessa, Paraskevi
Krämer, Nadine
Stoltenburg-Didinger, Gisela
Kaindl, Angela M.
CDK5RAP2 Is Required to Maintain the Germ Cell Pool during Embryonic Development
title CDK5RAP2 Is Required to Maintain the Germ Cell Pool during Embryonic Development
title_full CDK5RAP2 Is Required to Maintain the Germ Cell Pool during Embryonic Development
title_fullStr CDK5RAP2 Is Required to Maintain the Germ Cell Pool during Embryonic Development
title_full_unstemmed CDK5RAP2 Is Required to Maintain the Germ Cell Pool during Embryonic Development
title_short CDK5RAP2 Is Required to Maintain the Germ Cell Pool during Embryonic Development
title_sort cdk5rap2 is required to maintain the germ cell pool during embryonic development
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312265/
https://www.ncbi.nlm.nih.gov/pubmed/28162995
http://dx.doi.org/10.1016/j.stemcr.2017.01.002
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