Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia

Nucleophosmin (NPM1) is a multifunctional protein that is implicated in the pathogenesis of several human malignancies. To gain insight into the role of isolated fragments of NPM1 in its biological activities, we dissected the C-terminal domain (CTD) into its helical fragments. Here we focus the att...

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Detalles Bibliográficos
Autores principales: Scognamiglio, Pasqualina Liana, Di Natale, Concetta, Leone, Marilisa, Cascella, Roberta, Cecchi, Cristina, Lirussi, Lisa, Antoniali, Giulia, Riccardi, Domenico, Morelli, Giancarlo, Tell, Gianluca, Chiti, Fabrizio, Marasco, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312300/
https://www.ncbi.nlm.nih.gov/pubmed/27494862
http://dx.doi.org/10.18632/oncotarget.10991

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