Loss of zfp36 expression in colorectal cancer correlates to wnt/ β-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of zeb1, sox9 and macc1

The mRNA-destabilizing protein ZFP36 has been previously described as a tumor suppressor whose expression is lost during colorectal cancer development. In order to evaluate its role in this disease, we restored ZFP36 expression in different cell contexts, showing that the presence of this protein im...

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Detalles Bibliográficos
Autores principales: Montorsi, Lucia, Guizzetti, Filippo, Alecci, Claudia, Caporali, Andrea, Martello, Andrea, Atene, Claudio Giacinto, Parenti, Sandra, Pizzini, Silvia, Zanovello, Paola, Bortoluzzi, Stefania, Ferrari, Sergio, Grande, Alexis, Zanocco-Marani, Tommaso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312301/
https://www.ncbi.nlm.nih.gov/pubmed/27463018
http://dx.doi.org/10.18632/oncotarget.10828

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