Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells

Glioblastoma (GBM) is the most lethal and aggressive adult brain tumor, requiring the development of efficacious therapeutics. Towards this goal, we screened five genetically distinct patient-derived brain-tumor initiating cell lines (BTIC) with a unique collection of small molecule epigenetic modul...

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Detalles Bibliográficos
Autores principales: Grinshtein, Natalie, Rioseco, Constanza C., Marcellus, Richard, Uehling, David, Aman, Ahmed, Lun, Xueqing, Muto, Osamu, Podmore, Lauren, Lever, Jake, Shen, Yaoqing, Blough, Michael D., Cairncross, Greg J., Robbins, Stephen M., Jones, Steven J., Marra, Marco A., Al-Awar, Rima, Senger, Donna L., Kaplan, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312317/
https://www.ncbi.nlm.nih.gov/pubmed/27449082
http://dx.doi.org/10.18632/oncotarget.10661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312317/
https://www.ncbi.nlm.nih.gov/pubmed/27449082
http://dx.doi.org/10.18632/oncotarget.10661

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