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Dysregulated long intergenic non-coding RNA modules contribute to heart failure
Long intergenic non-coding RNAs (lincRNAs) are emerging as important regulatory molecules involved in diseases including heart failure. However, little is known about how the lincRNAs work together with protein-coding genes (PCGs) contributing to the pathogenesis of heart failure. In this study, we...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312340/ https://www.ncbi.nlm.nih.gov/pubmed/28040802 http://dx.doi.org/10.18632/oncotarget.10834 |
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author | Pang, Lin Hu, Jing Zhang, Guanxiong Li, Xiang Zhang, Xinxin Yu, Fulong Lan, Yujia Xu, Jinyuan Pang, Bo Han, Dong Xiao, Yun Li, Xia |
author_facet | Pang, Lin Hu, Jing Zhang, Guanxiong Li, Xiang Zhang, Xinxin Yu, Fulong Lan, Yujia Xu, Jinyuan Pang, Bo Han, Dong Xiao, Yun Li, Xia |
author_sort | Pang, Lin |
collection | PubMed |
description | Long intergenic non-coding RNAs (lincRNAs) are emerging as important regulatory molecules involved in diseases including heart failure. However, little is known about how the lincRNAs work together with protein-coding genes (PCGs) contributing to the pathogenesis of heart failure. In this study, we constructed a comprehensive transcriptome profile of lincRNAs, PCGs and miRNAs using RNA-seq and miRNA-seq data of 16 heart failure patients (HFs) and 8 non-failing individuals (NFs). Through integrating lincRNA and PCG expression profiles, we identified HF-associated lincRNA modules. We identified a heart-specific lincRNA module which was significantly enriched for differentially expressed lincRNAs and PCGs. This module was associated with heart failure rather than with other clinical traits such as sex, age, smoking and diabetes mellitus. Moreover, the module was significantly correlated with certain indicators of left ventricular function like ejection fraction and left ventricular end-diastolic diameter, implying the potential of its components as crucial biomarkers. Apart from enhancer-like function, lincRNAs in this module could act as competing endogenous RNAs (ceRNAs) to regulate genes which were associated with left-ventricular systolic function. Our work provided deep insights into the critical roles of lincRNAs in the pathology of heart failure and suggested that they could be valuable biomarkers and therapeutic targets. |
format | Online Article Text |
id | pubmed-5312340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53123402017-03-06 Dysregulated long intergenic non-coding RNA modules contribute to heart failure Pang, Lin Hu, Jing Zhang, Guanxiong Li, Xiang Zhang, Xinxin Yu, Fulong Lan, Yujia Xu, Jinyuan Pang, Bo Han, Dong Xiao, Yun Li, Xia Oncotarget Research Paper Long intergenic non-coding RNAs (lincRNAs) are emerging as important regulatory molecules involved in diseases including heart failure. However, little is known about how the lincRNAs work together with protein-coding genes (PCGs) contributing to the pathogenesis of heart failure. In this study, we constructed a comprehensive transcriptome profile of lincRNAs, PCGs and miRNAs using RNA-seq and miRNA-seq data of 16 heart failure patients (HFs) and 8 non-failing individuals (NFs). Through integrating lincRNA and PCG expression profiles, we identified HF-associated lincRNA modules. We identified a heart-specific lincRNA module which was significantly enriched for differentially expressed lincRNAs and PCGs. This module was associated with heart failure rather than with other clinical traits such as sex, age, smoking and diabetes mellitus. Moreover, the module was significantly correlated with certain indicators of left ventricular function like ejection fraction and left ventricular end-diastolic diameter, implying the potential of its components as crucial biomarkers. Apart from enhancer-like function, lincRNAs in this module could act as competing endogenous RNAs (ceRNAs) to regulate genes which were associated with left-ventricular systolic function. Our work provided deep insights into the critical roles of lincRNAs in the pathology of heart failure and suggested that they could be valuable biomarkers and therapeutic targets. Impact Journals LLC 2016-07-25 /pmc/articles/PMC5312340/ /pubmed/28040802 http://dx.doi.org/10.18632/oncotarget.10834 Text en Copyright: © 2016 Pang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Pang, Lin Hu, Jing Zhang, Guanxiong Li, Xiang Zhang, Xinxin Yu, Fulong Lan, Yujia Xu, Jinyuan Pang, Bo Han, Dong Xiao, Yun Li, Xia Dysregulated long intergenic non-coding RNA modules contribute to heart failure |
title | Dysregulated long intergenic non-coding RNA modules contribute to heart failure |
title_full | Dysregulated long intergenic non-coding RNA modules contribute to heart failure |
title_fullStr | Dysregulated long intergenic non-coding RNA modules contribute to heart failure |
title_full_unstemmed | Dysregulated long intergenic non-coding RNA modules contribute to heart failure |
title_short | Dysregulated long intergenic non-coding RNA modules contribute to heart failure |
title_sort | dysregulated long intergenic non-coding rna modules contribute to heart failure |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312340/ https://www.ncbi.nlm.nih.gov/pubmed/28040802 http://dx.doi.org/10.18632/oncotarget.10834 |
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