Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells

Isopropyl methanesulfonate (IPMS) is the most potent genotoxic compound among methanesulfonic acid esters. The genotoxic potential of alkyl sulfonate esters is believed to be due to their alkylating ability of the O6 position of guanine. Understanding the primary repair pathway activated in response...

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Detalles Bibliográficos
Autores principales: Hashimoto, Kiyohiro, Sharma, Vyom, Sasanuma, Hiroyuki, Tian, Xu, Takata, Minoru, Takeda, Shunichi, Swenberg, James A., Nakamura, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312349/
https://www.ncbi.nlm.nih.gov/pubmed/27486975
http://dx.doi.org/10.18632/oncotarget.10928

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