Cargando…

Downregulation of homeobox gene Barx2 increases gastric cancer proliferation and metastasis and predicts poor patient outcomes

Barx2 is a Bar family homeodomain transcription factor shown to play a critical role in cell adhesion and cytoskeleton remodeling, key processes in carcinogenesis and metastasis. Using quantitative real-time PCR, Western blotting, and immunohistochemistry, we found that Barx2 is expressed at lower l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mi, Yushuai, Zhao, Senlin, Zhou, Chongzhi, Weng, Junyong, Li, Jikun, Wang, Zhanshan, Sun, Huimin, Tang, Huamei, Zhang, Xin, Sun, Xiaofeng, Peng, Zhihai, Wen, Yugang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312404/ https://www.ncbi.nlm.nih.gov/pubmed/27533254 http://dx.doi.org/10.18632/oncotarget.11260

Ejemplares similares

The Homeobox Transcription Factor Barx2 Regulates Plasticity of Young Primary Myofibers
por: Meech, Robyn, et al.
Publicado: (2010)

miR-4775 promotes colorectal cancer invasion and metastasis via the Smad7/TGFβ-mediated epithelial to mesenchymal transition
por: Zhao, Senlin, et al.
Publicado: (2017)

MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4
por: Cheng, Dantong, et al.
Publicado: (2016)

PCDHGA9 acts as a tumor suppressor to induce tumor cell apoptosis and autophagy and inhibit the EMT process in human gastric cancer
por: Weng, Junyong, et al.
Publicado: (2018)

BARX2 expression is downregulated by CpG island hypermethylation and is associated with suppressed cell proliferation and invasion of gastric cancer cells
por: Ma, Juan, et al.
Publicado: (2020)

Loss of Barx1 promotes hepatocellular carcinoma metastasis through up-regulating MGAT5 and MMP9 expression and indicates poor prognosis
por: Wang, Guodong, et al.
Publicado: (2017)

BARX1 promotes osteosarcoma cell proliferation and invasion by regulating HSPA6 expression
por: Huang, Xing, et al.
Publicado: (2023)

Elevated HOXA13 expression promotes the proliferation and metastasis of gastric cancer partly via activating Erk1/2
por: Qin, Zhiwei, et al.
Publicado: (2019)

Immunohistochemical Localization of Barx2 in the Developing Fetal Mouse Submandibular Glands
por: Naka, Takahiro, et al.
Publicado: (2009)

Overexpression of RBBP6, Alone or Combined with Mutant TP53, Is Predictive of Poor Prognosis in Colon Cancer
por: Chen, Jian, et al.
Publicado: (2013)

Single nucleotide polymorphisms in CRTC1 and BARX1 are associated with esophageal adenocarcinoma
por: van Nistelrooij, Anna M. J., et al.
Publicado: (2015)

Loss of KLF4 and Consequential Downregulation of Smad7 Exacerbate Oncogenic TGF-β Signaling in and Promote Progression of Hepatocellular Carcinoma
por: Sun, Hongcheng, et al.
Publicado: (2017)

GATA4 as a novel regulator involved in the development of the neural crest and craniofacial skeleton via Barx1
por: Guo, Shuyu, et al.
Publicado: (2018)

Polymorphisms of the BARX1 and ADAMTS17 Locus Genes in Individuals With Gastroesophageal Reflux Disease
por: Argyrou, Alexandra, et al.
Publicado: (2019)

Pancancer analysis of oncogenic BARX2 identifying its prognostic value and immunological function in liver hepatocellular carcinoma
por: Yu, Shian, et al.
Publicado: (2023)

Homeobox B5 promotes metastasis and poor prognosis in Hepatocellular Carcinoma, via FGFR4 and CXCL1 upregulation
por: He, Qin, et al.
Publicado: (2021)

Downregulation of Homeobox B7 Inhibits the Tumorigenesis and Progression of Osteosarcoma
por: Yang, Lei, et al.
Publicado: (2017)

PCDHGA9 represses epithelial-mesenchymal transition and metastatic potential in gastric cancer cells by reducing β-catenin transcriptional activity
por: Weng, Junyong, et al.
Publicado: (2020)

High level of homeobox A9 and PBX homeobox 3 expression in gastric cancer correlates with poor prognosis
por: Ma, Ying-Yu, et al.
Publicado: (2017)

DDA1 promotes stage IIB–IIC colon cancer progression by activating NFκB/CSN2/GSK-3β signaling
por: Zhao, Senlin, et al.
Publicado: (2016)

Transcription Factors BARX1 and DLX4 Contribute to Progression of Clear Cell Renal Cell Carcinoma via Promoting Proliferation and Epithelial–Mesenchymal Transition
por: Sun, Guoliang, et al.
Publicado: (2021)

Supportive evidence for FOXP1, BARX1, and FOXF1 as genetic risk loci for the development of esophageal adenocarcinoma
por: Becker, Jessica, et al.
Publicado: (2015)

Up-regulation of miR-187 modulates the advances of oral carcinoma by targeting BARX2 tumor suppressor
por: Lin, Shu-Chun, et al.
Publicado: (2016)

BARX2/FOXA1/HK2 axis promotes lung adenocarcinoma progression and energy metabolism reprogramming
por: Xie, Kai, et al.
Publicado: (2022)

ZFP36 loss-mediated BARX1 stabilization promotes malignant phenotypes by transactivating master oncogenes in NSCLC
por: Zhang, Tongjia, et al.
Publicado: (2023)

Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer
por: Wang, Xiao, et al.
Publicado: (2016)

Correction to: Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer
por: Wang, Xiao, et al.
Publicado: (2018)

Corrigendum: Transcription factors BARX1 and DLX4 contribute to progression of clear cell renal cell carcinoma via promoting proliferation and epithelial–mesenchymal transition
por: Sun, Guoliang, et al.
Publicado: (2022)

A comparative analysis and guidance for individualized chemotherapy of stage II and III colorectal cancer patients based on pathological markers
por: Han, Yang, et al.
Publicado: (2016)

Upregulation of homeobox gene is correlated with poor survival outcomes in cervical cancer
por: Eoh, Kyung Jin, et al.
Publicado: (2017)

Barx1-Mediated Inhibition of Wnt Signaling in the Mouse Thoracic Foregut Controls Tracheo-Esophageal Septation and Epithelial Differentiation
por: Woo, Janghee, et al.
Publicado: (2011)

The Homeobox Only Protein Homeobox (HOPX) and Colorectal Cancer
por: Yamashita, Keishi, et al.
Publicado: (2013)

Circular RNA circSHPRH inhibits the malignant behaviors of bladder cancer by regulating the miR-942/BARX2 pathway
por: Zuo, Ling, et al.
Publicado: (2022)

Immunohistochemical Evaluation of BARX1, DLX4, FOXE1, HOXB3, and MSX2 in Nonsyndromic Cleft Affected Tissue
por: Vaivads, Mārtiņš, et al.
Publicado: (2022)

Karyopherin alpha 2 is a novel prognostic marker and a potential therapeutic target for colon cancer
por: Zhang, Yu, et al.
Publicado: (2015)

VEGI downregulation is correlated with nodal metastasis and poor prognosis in lung adenocarcinoma
por: Xu, Yinhai, et al.
Publicado: (2021)

Dorsal Root Ganglia Homeobox downregulation in primary sensory neurons contributes to neuropathic pain in rats
por: Ito, Takaya, et al.
Publicado: (2020)

Highly‐metastatic colorectal cancer cell released miR‐181a‐5p‐rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling the tumour microenvironment
por: Zhao, Senlin, et al.
Publicado: (2022)

Elevated HOXA1 expression correlates with accelerated tumor cell proliferation and poor prognosis in gastric cancer partly via cyclin D1
por: Yuan, Chenwei, et al.
Publicado: (2016)

The Metastasis Suppressor, N-myc Downregulated Gene 1 (NDRG1), Is a Prognostic Biomarker for Human Colorectal Cancer
por: Mao, Zhihai, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_8ckmh38irnhhhp0se7ldfe8dlu