Microenvironment drug resistance in multiple myeloma: emerging new players

Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on a powerful interplay between bone marrow stromal cells and MM cells that allows the latter to escape anti-myeloma therapies. Here we present an overview of the role of the bone marrow microenvironment in both s...

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Detalles Bibliográficos
Autores principales: Di Marzo, Lucia, Desantis, Vanessa, Solimando, Antonio Giovanni, Ruggieri, Simona, Annese, Tiziana, Nico, Beatrice, Fumarulo, Ruggiero, Vacca, Angelo, Frassanito, Maria Antonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312413/
https://www.ncbi.nlm.nih.gov/pubmed/27474171
http://dx.doi.org/10.18632/oncotarget.10849
Descripción
Sumario:Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on a powerful interplay between bone marrow stromal cells and MM cells that allows the latter to escape anti-myeloma therapies. Here we present an overview of the role of the bone marrow microenvironment in both soluble factors-mediated drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAM-DR), focusing on the role of new players, namely miRNAs, exosomes and cancer-associated fibroblasts.

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