Microenvironment drug resistance in multiple myeloma: emerging new players

Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on a powerful interplay between bone marrow stromal cells and MM cells that allows the latter to escape anti-myeloma therapies. Here we present an overview of the role of the bone marrow microenvironment in both s...

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Autores principales: Di Marzo, Lucia, Desantis, Vanessa, Solimando, Antonio Giovanni, Ruggieri, Simona, Annese, Tiziana, Nico, Beatrice, Fumarulo, Ruggiero, Vacca, Angelo, Frassanito, Maria Antonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312413/
https://www.ncbi.nlm.nih.gov/pubmed/27474171
http://dx.doi.org/10.18632/oncotarget.10849
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author Di Marzo, Lucia
Desantis, Vanessa
Solimando, Antonio Giovanni
Ruggieri, Simona
Annese, Tiziana
Nico, Beatrice
Fumarulo, Ruggiero
Vacca, Angelo
Frassanito, Maria Antonia
author_facet Di Marzo, Lucia
Desantis, Vanessa
Solimando, Antonio Giovanni
Ruggieri, Simona
Annese, Tiziana
Nico, Beatrice
Fumarulo, Ruggiero
Vacca, Angelo
Frassanito, Maria Antonia
author_sort Di Marzo, Lucia
collection PubMed
description Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on a powerful interplay between bone marrow stromal cells and MM cells that allows the latter to escape anti-myeloma therapies. Here we present an overview of the role of the bone marrow microenvironment in both soluble factors-mediated drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAM-DR), focusing on the role of new players, namely miRNAs, exosomes and cancer-associated fibroblasts.
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spelling pubmed-53124132017-03-06 Microenvironment drug resistance in multiple myeloma: emerging new players Di Marzo, Lucia Desantis, Vanessa Solimando, Antonio Giovanni Ruggieri, Simona Annese, Tiziana Nico, Beatrice Fumarulo, Ruggiero Vacca, Angelo Frassanito, Maria Antonia Oncotarget Review Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on a powerful interplay between bone marrow stromal cells and MM cells that allows the latter to escape anti-myeloma therapies. Here we present an overview of the role of the bone marrow microenvironment in both soluble factors-mediated drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAM-DR), focusing on the role of new players, namely miRNAs, exosomes and cancer-associated fibroblasts. Impact Journals LLC 2016-07-26 /pmc/articles/PMC5312413/ /pubmed/27474171 http://dx.doi.org/10.18632/oncotarget.10849 Text en Copyright: © 2016 Marzo et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Di Marzo, Lucia
Desantis, Vanessa
Solimando, Antonio Giovanni
Ruggieri, Simona
Annese, Tiziana
Nico, Beatrice
Fumarulo, Ruggiero
Vacca, Angelo
Frassanito, Maria Antonia
Microenvironment drug resistance in multiple myeloma: emerging new players
title Microenvironment drug resistance in multiple myeloma: emerging new players
title_full Microenvironment drug resistance in multiple myeloma: emerging new players
title_fullStr Microenvironment drug resistance in multiple myeloma: emerging new players
title_full_unstemmed Microenvironment drug resistance in multiple myeloma: emerging new players
title_short Microenvironment drug resistance in multiple myeloma: emerging new players
title_sort microenvironment drug resistance in multiple myeloma: emerging new players
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312413/
https://www.ncbi.nlm.nih.gov/pubmed/27474171
http://dx.doi.org/10.18632/oncotarget.10849
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