Cargando…

Microenvironment drug resistance in multiple myeloma: emerging new players

Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on a powerful interplay between bone marrow stromal cells and MM cells that allows the latter to escape anti-myeloma therapies. Here we present an overview of the role of the bone marrow microenvironment in both s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di Marzo, Lucia, Desantis, Vanessa, Solimando, Antonio Giovanni, Ruggieri, Simona, Annese, Tiziana, Nico, Beatrice, Fumarulo, Ruggiero, Vacca, Angelo, Frassanito, Maria Antonia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312413/ https://www.ncbi.nlm.nih.gov/pubmed/27474171 http://dx.doi.org/10.18632/oncotarget.10849

Ejemplares similares

Mechanisms of Resistance to Anti-CD38 Daratumumab in Multiple Myeloma
por: Saltarella, Ilaria, et al.
Publicado: (2020)

Inhibition of mTOR complex 2 restrains tumor angiogenesis in multiple myeloma
por: Lamanuzzi, Aurelia, et al.
Publicado: (2018)

MicroRNAs-Based Nano-Strategies as New Therapeutic Approach in Multiple Myeloma to Overcome Disease Progression and Drug Resistance
por: Desantis, Vanessa, et al.
Publicado: (2020)

Homotypic and Heterotypic Activation of the Notch Pathway in Multiple Myeloma–Enhanced Angiogenesis: A Novel Therapeutic Target?()
por: Saltarella, Ilaria, et al.
Publicado: (2018)

The Leading Role of the Immune Microenvironment in Multiple Myeloma: A New Target with a Great Prognostic and Clinical Value
por: Desantis, Vanessa, et al.
Publicado: (2022)

Multiple Myeloma Macrophages: Pivotal Players in the Tumor Microenvironment
por: Berardi, Simona, et al.
Publicado: (2013)

Role of Extracellular Vesicle-Based Cell-to-Cell Communication in Multiple Myeloma Progression
por: Saltarella, Ilaria, et al.
Publicado: (2021)

MicroRNAs as a Potential New Preventive Approach in the Transition from Asymptomatic to Symptomatic Multiple Myeloma Disease
por: Desantis, Vanessa, et al.
Publicado: (2021)

Role of erythropoietin in the angiogenic activity of bone marrow endothelial cells of MGUS and multiple myeloma patients
por: Lamanuzzi, Aurelia, et al.
Publicado: (2016)

High-Risk Multiple Myeloma: Integrated Clinical and Omics Approach Dissects the Neoplastic Clone and the Tumor Microenvironment
por: Solimando, Antonio Giovanni, et al.
Publicado: (2019)

Uptake-Dependent and -Independent Effects of Fibroblasts-Derived Extracellular Vesicles on Bone Marrow Endothelial Cells from Patients with Multiple Myeloma: Therapeutic and Clinical Implications
por: Lamanuzzi, Aurelia, et al.
Publicado: (2023)

Pathways of Angiogenic and Inflammatory Cytokines in Multiple Myeloma: Role in Plasma Cell Clonal Expansion and Drug Resistance
por: Melaccio, Assunta, et al.
Publicado: (2022)

The Landscape of lncRNAs in Multiple Myeloma: Implications in the “Hallmarks of Cancer”, Clinical Perspectives and Therapeutic Opportunities
por: Saltarella, Ilaria, et al.
Publicado: (2022)

Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin(®) protein MP0250: a preclinical study
por: Rao, Luigia, et al.
Publicado: (2018)

Autophagy: A New Mechanism of Prosurvival and Drug Resistance in Multiple Myeloma
por: Desantis, V., et al.
Publicado: (2018)

Induction Therapy and Stem Cell Mobilization in Patients with Newly Diagnosed Multiple Myeloma
por: Ria, Roberto, et al.
Publicado: (2012)

Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma
por: De Veirman, Kim, et al.
Publicado: (2014)

New Insights into Diffuse Large B-Cell Lymphoma Pathobiology
por: Solimando, Antonio Giovanni, et al.
Publicado: (2020)

A Comprehensive Biological and Clinical Perspective Can Drive a Patient-Tailored Approach to Multiple Myeloma: Bridging the Gaps between the Plasma Cell and the Neoplastic Niche
por: Solimando, Antonio Giovanni, et al.
Publicado: (2020)

Anti-Angiogenic Activity of Drugs in Multiple Myeloma
por: Saltarella, Ilaria, et al.
Publicado: (2023)

Ion Channels in Multiple Myeloma: Pathogenic Role and Therapeutic Perspectives
por: Saltarella, Ilaria, et al.
Publicado: (2022)

Bcl6/p53 expression, macrophages/mast cells infiltration and microvascular density in invasive breast carcinoma
por: Tamma, Roberto, et al.
Publicado: (2018)

The Urgent Need for Precision Medicine in Cancer and Its Microenvironment: The Paradigmatic Case of Multiple Myeloma
por: Solimando, Antonio Giovanni, et al.
Publicado: (2022)

JAM-A as a prognostic factor and new therapeutic target in multiple myeloma
por: Solimando, A G, et al.
Publicado: (2018)

microRNAs as Biomarkers of Endothelial Dysfunction and Therapeutic Target in the Pathogenesis of Atrial Fibrillation
por: Desantis, Vanessa, et al.
Publicado: (2023)

Mast Cells and Interleukins
por: Solimando, Antonio Giovanni, et al.
Publicado: (2022)

NK cells and multiple myeloma-associated endothelial cells: molecular interactions and influence of IL-27
por: Dondero, Alessandra, et al.
Publicado: (2017)

Dp71 Expression in Human Glioblastoma
por: Ruggieri, Simona, et al.
Publicado: (2019)

Cancer-Associated Angiogenesis: The Endothelial Cell as a Checkpoint for Immunological Patrolling
por: Solimando, Antonio Giovanni, et al.
Publicado: (2020)

A multiple myeloma that progressed as type I cryoglobulinemia with skin ulcers and foot necrosis: A case report
por: Solimando, Antonio G., et al.
Publicado: (2018)

Angiogenesis in Pancreatic Cancer: Pre-Clinical and Clinical Studies
por: Annese, Tiziana, et al.
Publicado: (2019)

Actors on the Scene: Immune Cells in the Myeloma Niche
por: Leone, Patrizia, et al.
Publicado: (2020)

Bortezomib Treatment Modulates Autophagy in Multiple Myeloma
por: Di Lernia, Giuseppe, et al.
Publicado: (2020)

Bone Marrow CX3CL1/Fractalkine is a New Player of the Pro-Angiogenic Microenvironment in Multiple Myeloma Patients
por: Marchica, Valentina, et al.
Publicado: (2019)

Epha3 acts as proangiogenic factor in multiple myeloma
por: Caivano, Antonella, et al.
Publicado: (2017)

Breaking through Multiple Myeloma: A Paradigm for a Comprehensive Tumor Ecosystem Targeting
por: Solimando, Antonio G., et al.
Publicado: (2023)

Limitations of Anti-Angiogenic Treatment of Tumors
por: Ribatti, Domenico, et al.
Publicado: (2019)

Cardiovascular Risk in Patients With Takayasu Arteritis Directly Correlates With Diastolic Dysfunction and Inflammatory Cell Infiltration in the Vessel Wall: A Clinical, ex vivo and in vitro Analysis
por: Cicco, Sebastiano, et al.
Publicado: (2022)

Angiogenic activity of multiple myeloma endothelial cells in vivo in the chick embryo chorioallantoic membrane assay is associated to a down-regulation in the expression of endogenous endostatin
por: Mangieri, Domenica, et al.
Publicado: (2008)

Stat3-positive tumor cells contribute to vessels neoformation in primary central nervous system lymphoma
por: Ruggieri, Simona, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_lp5b3gt8g6cpij2p2rtser6ci9