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Inguinal lymph node presenting as the delayed site of metastasis in early stage endometrial carcinoma: Case report

INTRODUCTION: Inguinal lymph nodes are the frequent sites of metastasis for malignant lymphoma, squamous cell carcinoma of anal canal, vulva and penis, malignant melanoma and squamous cell carcinoma of skin over lower extremities or trunk. Anatomically, endometrial carcinoma is less likely to spread...

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Autores principales: Akbar, Shomaila Amir M., Tunio, Mutahir A., AlShakweer, Wafa, AlObaid, AbdulAziz, AlAsiri, Mushabbab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312497/
https://www.ncbi.nlm.nih.gov/pubmed/28213066
http://dx.doi.org/10.1016/j.ijscr.2017.01.045
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author Akbar, Shomaila Amir M.
Tunio, Mutahir A.
AlShakweer, Wafa
AlObaid, AbdulAziz
AlAsiri, Mushabbab
author_facet Akbar, Shomaila Amir M.
Tunio, Mutahir A.
AlShakweer, Wafa
AlObaid, AbdulAziz
AlAsiri, Mushabbab
author_sort Akbar, Shomaila Amir M.
collection PubMed
description INTRODUCTION: Inguinal lymph nodes are the frequent sites of metastasis for malignant lymphoma, squamous cell carcinoma of anal canal, vulva and penis, malignant melanoma and squamous cell carcinoma of skin over lower extremities or trunk. Anatomically, endometrial carcinoma is less likely to spread to the superficial or deep inguinal lymph nodes, thus metastatic involvement of these lymph nodes can easily be overlooked. CASE PRESENTATION: Here-in we report a case of a 65-year old Saudi morbid obese female, who presented with left inguinal lymphadenopathy as initial delayed site of metastasis almost 19 months after the initial treatment for FIGO IA endometrial carcinoma. Patient underwent left inguinal lymph node dissection. Histopathology confirmed metastatic endometrial adenocarcinoma, positive for cytokeratin (CK-7), estrogen receptor (ER) and progesterone receptors (PR), negative for CK-20 and CDX2. Following the post-surgery recovery, she was given extended field radiation therapy to para-aortic, pelvis and bilateral inguinal lymph nodes with concurrent cisplatin chemotherapy followed by high dose rate brachytherapy. CONCLUSION: Inguinal lymph nodes as delayed site of metastasis in early endometrial carcinoma is extremely rare entity. Incorporation of FDG-PET during the preoperative screening of inguinal nodes may be helpful. The impact of lymph node dissection and adjuvant radiation therapy on survival needs to be established.
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spelling pubmed-53124972017-02-22 Inguinal lymph node presenting as the delayed site of metastasis in early stage endometrial carcinoma: Case report Akbar, Shomaila Amir M. Tunio, Mutahir A. AlShakweer, Wafa AlObaid, AbdulAziz AlAsiri, Mushabbab Int J Surg Case Rep Case Report INTRODUCTION: Inguinal lymph nodes are the frequent sites of metastasis for malignant lymphoma, squamous cell carcinoma of anal canal, vulva and penis, malignant melanoma and squamous cell carcinoma of skin over lower extremities or trunk. Anatomically, endometrial carcinoma is less likely to spread to the superficial or deep inguinal lymph nodes, thus metastatic involvement of these lymph nodes can easily be overlooked. CASE PRESENTATION: Here-in we report a case of a 65-year old Saudi morbid obese female, who presented with left inguinal lymphadenopathy as initial delayed site of metastasis almost 19 months after the initial treatment for FIGO IA endometrial carcinoma. Patient underwent left inguinal lymph node dissection. Histopathology confirmed metastatic endometrial adenocarcinoma, positive for cytokeratin (CK-7), estrogen receptor (ER) and progesterone receptors (PR), negative for CK-20 and CDX2. Following the post-surgery recovery, she was given extended field radiation therapy to para-aortic, pelvis and bilateral inguinal lymph nodes with concurrent cisplatin chemotherapy followed by high dose rate brachytherapy. CONCLUSION: Inguinal lymph nodes as delayed site of metastasis in early endometrial carcinoma is extremely rare entity. Incorporation of FDG-PET during the preoperative screening of inguinal nodes may be helpful. The impact of lymph node dissection and adjuvant radiation therapy on survival needs to be established. Elsevier 2017-01-19 /pmc/articles/PMC5312497/ /pubmed/28213066 http://dx.doi.org/10.1016/j.ijscr.2017.01.045 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Akbar, Shomaila Amir M.
Tunio, Mutahir A.
AlShakweer, Wafa
AlObaid, AbdulAziz
AlAsiri, Mushabbab
Inguinal lymph node presenting as the delayed site of metastasis in early stage endometrial carcinoma: Case report
title Inguinal lymph node presenting as the delayed site of metastasis in early stage endometrial carcinoma: Case report
title_full Inguinal lymph node presenting as the delayed site of metastasis in early stage endometrial carcinoma: Case report
title_fullStr Inguinal lymph node presenting as the delayed site of metastasis in early stage endometrial carcinoma: Case report
title_full_unstemmed Inguinal lymph node presenting as the delayed site of metastasis in early stage endometrial carcinoma: Case report
title_short Inguinal lymph node presenting as the delayed site of metastasis in early stage endometrial carcinoma: Case report
title_sort inguinal lymph node presenting as the delayed site of metastasis in early stage endometrial carcinoma: case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312497/
https://www.ncbi.nlm.nih.gov/pubmed/28213066
http://dx.doi.org/10.1016/j.ijscr.2017.01.045
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