Aprepitant limits in vivo neuroinflammatory responses in a rhesus model of Lyme neuroborreliosis

BACKGROUND: Substance P (SP) is produced at high levels in the central nervous system (CNS), and its target receptor, neurokinin 1 receptor (NK-1R), is expressed by glia and leukocytes. This tachykinin functions to exacerbate inflammatory responses at peripheral sites. Moreover, SP/NK-1R interaction...

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Detalles Bibliográficos
Autores principales: Martinez, Alejandra N., Burmeister, Amanda R., Ramesh, Geeta, Doyle-Meyers, Lara, Marriott, Ian, Philipp, Mario T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312540/
https://www.ncbi.nlm.nih.gov/pubmed/28202084
http://dx.doi.org/10.1186/s12974-017-0813-x

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