Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

Synaptic loss and neuron death are the underlying cause of neurodegenerative diseases such as Alzheimer's disease (AD); however, the modalities of cell death in those diseases remain unclear. Ferroptosis, a newly identified oxidative cell death mechanism triggered by massive lipid peroxidation,...

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Detalles Bibliográficos
Autores principales: Hambright, William Sealy, Fonseca, Rene Solano, Chen, Liuji, Na, Ren, Ran, Qitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312549/
https://www.ncbi.nlm.nih.gov/pubmed/28212525
http://dx.doi.org/10.1016/j.redox.2017.01.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312549/
https://www.ncbi.nlm.nih.gov/pubmed/28212525
http://dx.doi.org/10.1016/j.redox.2017.01.021

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