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DNA methylation data for identification of epigenetic targets of resveratrol in triple negative breast cancer cells
Previous studies revealed that some bioactive food components have anti-cancer effects. However epigenetic effects of dietary compound resveratrol are largely unknown in breast cancer cells (M.A. Dawson, T. Kouzarides, 2012) [1]. Here we provide novel data and comparisons of DNA methylation status o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312642/ https://www.ncbi.nlm.nih.gov/pubmed/28229117 http://dx.doi.org/10.1016/j.dib.2017.02.006 |
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author | Medina-Aguilar, Rubiceli Pérez-Plasencia, Carlos Gariglio, Patricio Marchat, Laurence A. Flores-Pérez, Ali López-Camarillo, César García Mena, Jaime |
author_facet | Medina-Aguilar, Rubiceli Pérez-Plasencia, Carlos Gariglio, Patricio Marchat, Laurence A. Flores-Pérez, Ali López-Camarillo, César García Mena, Jaime |
author_sort | Medina-Aguilar, Rubiceli |
collection | PubMed |
description | Previous studies revealed that some bioactive food components have anti-cancer effects. However epigenetic effects of dietary compound resveratrol are largely unknown in breast cancer cells (M.A. Dawson, T. Kouzarides, 2012) [1]. Here we provide novel data and comparisons of DNA methylation status of promoter gene regions in response to resveratrol treatment at 24 h and 48 h versus untreated MDA-MB-231 breast cancer cells. DNA methylation changes were measured using Array-PRIMES method (aPRIMES) followed by whole-genome hybridization using human DNA methylation promoter microarray NimbleGen HG18 Refseq Promoter 3×720 K array. Our data were associated to corresponding changes in mRNA expression in a set of cancer-related genes. Using gene ontology analysis we also identify cancer-related cellular processes and pathways that can be epigenetically reprogramed by resveratrol. Data in this article are associated to the research articles “Methylation Landscape of Human Breast Cancer Cells in Response to Dietary Compound Resveratrol”. Medina Aguilar et al., PLoS ONE 11(6): e0157866. doi:10.1371/journal.pone.0157866 2016 (A.R. Medina, P.C. Pérez, L.A. Marchat, P. Gariglio, M.J. García, C.S. Rodríguez, G.E. Ruíz, et al., 2016) [2]; and “Resveratrol inhibits cell cycle progression by targeting Aurora kinase A and Polo-like kinase 1 in breast cancer cells” in Oncology Reports. Medina Aguilar et al., 2016 Jun; 35(6):3696-704. doi: 10.3892/or.2016.4728 (A.R. Medina, P. Gariglio, M.J. García, O.E. Arechaga, S.N. Villegas, C.M. Martínez et al., 2016) [3]. |
format | Online Article Text |
id | pubmed-5312642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-53126422017-02-22 DNA methylation data for identification of epigenetic targets of resveratrol in triple negative breast cancer cells Medina-Aguilar, Rubiceli Pérez-Plasencia, Carlos Gariglio, Patricio Marchat, Laurence A. Flores-Pérez, Ali López-Camarillo, César García Mena, Jaime Data Brief Medicine and Dentistry Previous studies revealed that some bioactive food components have anti-cancer effects. However epigenetic effects of dietary compound resveratrol are largely unknown in breast cancer cells (M.A. Dawson, T. Kouzarides, 2012) [1]. Here we provide novel data and comparisons of DNA methylation status of promoter gene regions in response to resveratrol treatment at 24 h and 48 h versus untreated MDA-MB-231 breast cancer cells. DNA methylation changes were measured using Array-PRIMES method (aPRIMES) followed by whole-genome hybridization using human DNA methylation promoter microarray NimbleGen HG18 Refseq Promoter 3×720 K array. Our data were associated to corresponding changes in mRNA expression in a set of cancer-related genes. Using gene ontology analysis we also identify cancer-related cellular processes and pathways that can be epigenetically reprogramed by resveratrol. Data in this article are associated to the research articles “Methylation Landscape of Human Breast Cancer Cells in Response to Dietary Compound Resveratrol”. Medina Aguilar et al., PLoS ONE 11(6): e0157866. doi:10.1371/journal.pone.0157866 2016 (A.R. Medina, P.C. Pérez, L.A. Marchat, P. Gariglio, M.J. García, C.S. Rodríguez, G.E. Ruíz, et al., 2016) [2]; and “Resveratrol inhibits cell cycle progression by targeting Aurora kinase A and Polo-like kinase 1 in breast cancer cells” in Oncology Reports. Medina Aguilar et al., 2016 Jun; 35(6):3696-704. doi: 10.3892/or.2016.4728 (A.R. Medina, P. Gariglio, M.J. García, O.E. Arechaga, S.N. Villegas, C.M. Martínez et al., 2016) [3]. Elsevier 2017-02-09 /pmc/articles/PMC5312642/ /pubmed/28229117 http://dx.doi.org/10.1016/j.dib.2017.02.006 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Medicine and Dentistry Medina-Aguilar, Rubiceli Pérez-Plasencia, Carlos Gariglio, Patricio Marchat, Laurence A. Flores-Pérez, Ali López-Camarillo, César García Mena, Jaime DNA methylation data for identification of epigenetic targets of resveratrol in triple negative breast cancer cells |
title | DNA methylation data for identification of epigenetic targets of resveratrol in triple negative breast cancer cells |
title_full | DNA methylation data for identification of epigenetic targets of resveratrol in triple negative breast cancer cells |
title_fullStr | DNA methylation data for identification of epigenetic targets of resveratrol in triple negative breast cancer cells |
title_full_unstemmed | DNA methylation data for identification of epigenetic targets of resveratrol in triple negative breast cancer cells |
title_short | DNA methylation data for identification of epigenetic targets of resveratrol in triple negative breast cancer cells |
title_sort | dna methylation data for identification of epigenetic targets of resveratrol in triple negative breast cancer cells |
topic | Medicine and Dentistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312642/ https://www.ncbi.nlm.nih.gov/pubmed/28229117 http://dx.doi.org/10.1016/j.dib.2017.02.006 |
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