Overexpression of NOTCH-regulated Ankyrin Repeat Protein is associated with papillary thyroid carcinoma progression

Papillary thyroid cancer (PTC) is one of the endocrine cancers with high clinical and genetic heterogeneity. NOTCH signaling and its downstream NOTCH-Regulated Ankyrin Repeat Protein (NRARP) have been implicated in oncogenesis of many cancers, but the roles in PTCs are less studied. In this study, w...

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Autores principales: Zhang, Mingdi, Qin, Yiyu, Zuo, Bin, Gong, Wei, Zhang, Shenglai, Gong, Yurong, Quan, Zhiwei, Chu, Bingfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312965/
https://www.ncbi.nlm.nih.gov/pubmed/28207739
http://dx.doi.org/10.1371/journal.pone.0167782
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author Zhang, Mingdi
Qin, Yiyu
Zuo, Bin
Gong, Wei
Zhang, Shenglai
Gong, Yurong
Quan, Zhiwei
Chu, Bingfeng
author_facet Zhang, Mingdi
Qin, Yiyu
Zuo, Bin
Gong, Wei
Zhang, Shenglai
Gong, Yurong
Quan, Zhiwei
Chu, Bingfeng
author_sort Zhang, Mingdi
collection PubMed
description Papillary thyroid cancer (PTC) is one of the endocrine cancers with high clinical and genetic heterogeneity. NOTCH signaling and its downstream NOTCH-Regulated Ankyrin Repeat Protein (NRARP) have been implicated in oncogenesis of many cancers, but the roles in PTCs are less studied. In this study, we show that NRARP is frequently over-expressed in thyroid carcinoma. The over-activation of NRARP is highly and positively correlated with NOTCH genes. Moreover, we find that the expression of NRARP is highly associated with several epithelial mesenchymal transition (EMT) markers and contributes to poor survival outcomes. Therefore, these results indicate that NRARP is an important clinical biomarker in thyroid carcinoma and it promotes EMT induction as well as the progression of PTCs via NOTCH signaling activation.
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spelling pubmed-53129652017-03-03 Overexpression of NOTCH-regulated Ankyrin Repeat Protein is associated with papillary thyroid carcinoma progression Zhang, Mingdi Qin, Yiyu Zuo, Bin Gong, Wei Zhang, Shenglai Gong, Yurong Quan, Zhiwei Chu, Bingfeng PLoS One Research Article Papillary thyroid cancer (PTC) is one of the endocrine cancers with high clinical and genetic heterogeneity. NOTCH signaling and its downstream NOTCH-Regulated Ankyrin Repeat Protein (NRARP) have been implicated in oncogenesis of many cancers, but the roles in PTCs are less studied. In this study, we show that NRARP is frequently over-expressed in thyroid carcinoma. The over-activation of NRARP is highly and positively correlated with NOTCH genes. Moreover, we find that the expression of NRARP is highly associated with several epithelial mesenchymal transition (EMT) markers and contributes to poor survival outcomes. Therefore, these results indicate that NRARP is an important clinical biomarker in thyroid carcinoma and it promotes EMT induction as well as the progression of PTCs via NOTCH signaling activation. Public Library of Science 2017-02-16 /pmc/articles/PMC5312965/ /pubmed/28207739 http://dx.doi.org/10.1371/journal.pone.0167782 Text en © 2017 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zhang, Mingdi
Qin, Yiyu
Zuo, Bin
Gong, Wei
Zhang, Shenglai
Gong, Yurong
Quan, Zhiwei
Chu, Bingfeng
Overexpression of NOTCH-regulated Ankyrin Repeat Protein is associated with papillary thyroid carcinoma progression
title Overexpression of NOTCH-regulated Ankyrin Repeat Protein is associated with papillary thyroid carcinoma progression
title_full Overexpression of NOTCH-regulated Ankyrin Repeat Protein is associated with papillary thyroid carcinoma progression
title_fullStr Overexpression of NOTCH-regulated Ankyrin Repeat Protein is associated with papillary thyroid carcinoma progression
title_full_unstemmed Overexpression of NOTCH-regulated Ankyrin Repeat Protein is associated with papillary thyroid carcinoma progression
title_short Overexpression of NOTCH-regulated Ankyrin Repeat Protein is associated with papillary thyroid carcinoma progression
title_sort overexpression of notch-regulated ankyrin repeat protein is associated with papillary thyroid carcinoma progression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312965/
https://www.ncbi.nlm.nih.gov/pubmed/28207739
http://dx.doi.org/10.1371/journal.pone.0167782
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